2 documents found, page 1 of 1
One-carbon metabolism and global DNA methylation in mothers of individuals with...
Mendes, Cristiani Cortez; Zampieri, Bruna Lancia; Arantes, Lidia Maria Rebolho Batista; Melendez, Matias Eliseo; Biselli, Joice Matos [UNESP]Made available in DSpace on 2022-04-29T08:32:07Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-11-01; Down syndrome (DS) is the most common chromosomal disorder, resulting from the failure of normal chromosome 21 segregation. Studies have suggested that impairments within the one-carbon metabolic pathway can be of relevance for the global genome instability observed in mothers of individuals with DS. Ba...
Improved serological detection of rheumatoid arthritis: a highly antigenic mimo...
Araujo, Galber Rodrigues; Vaz, Emília Rezende; Fujimura, Patricia Tiemi; Fonseca, João Eurico; de Lima, Lucélia Maria; Canhao, HelenaIntroduction: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that affects around 1% of the human population worldwide. RA diagnosis can be difficult as there is no definitive test for its detection. Therefore, the aim of this study was to identify biomarkers that could be used for RA diagnosis. Methods: Sera from a collagen-induced arthritis mouse model were used to select potential biom...