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Effect of the secretory small GTPase Rab27B on breast cancer growth, invasion, ...

Hendrix, An; Maynard, Dawn; Pauwels, Patrick; Braems, Geert; Denys, Hannelore; Van Den Broecke, Rudy; Lambert, Jo; Van Belle, Simon; Cocquyt, Veronique

Background Secretory GTPases like Rab27B control vesicle exocytosis and deliver critical proinvasive growth regulators into the tumor microenvironment. The expression and role of Rab27B in breast cancer were unknown. Methods Expression of green fluorescent protein (GFP) fused with wild-type Rab3D, Rab27A, or Rab27B, or Rab27B point mutants defective in GTP/GDP binding or geranylgeranylation, or transient silenc...

Date: 2010   |   Origin: Repositório Institucional da UNL
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