4 documents found, page 1 of 1
Editorial: Herbal medical products and natural products targeting aging and age...
Ullah, Hammad; Khan, Haroon; Prieto Lage, Miguel A.; Daglia, MariaThe population aged ≥60 years is growing worldwide. The World Health Organization (WHO) reported that the elderly population is expected to increase from 1 billion in 2020 to 1.4 billion in 2030 and 2.1 billion in 2050 (World Health Organization, 2022). This increase in life expectancy around the globe is accompanied with the enhancing frequency of agingassociated disorders, mainly due to the deterioration of m...
Kaempferol: a key emphasis to its anticancer potential
Imran, Muhammad; Salehi, Bahare; Sharifi-Rad, Javad; Gondal, Tanweer; Saeed, Farhan; Imran, Ali; Shahbaz, Muhammad; Fokou, Patrick; Khan, HaroonA marked decrease in human cancers, including breast cancer, bone cancer, and cervical cancer, has been linked to the consumption of vegetable and fruit, and the corresponding chemoprotective e ect has been associated with the presence of several active molecules, such as kaempferol. Kaempferol is a major flavonoid aglycone found in many natural products, such as beans, bee pollen, broccoli, cabbage, capers, ca...
Targeting NF-κB signaling pathway in cancer by dietary polyphenols
Khan, Haroon; Ullah, Hammad; Castilho, Paula Cristina Machado Ferreira; Gomila, Antoni Sureda; D'Onofrio, Grazia; Filosa, Rosanna; Wang, FangBeing a transcription factor, NF-κB regulates gene expressions involving cell survival and proliferation, drug resistance, metastasis, and angiogenesis. The activation of NF-κB plays a central role in the development of inflammation and cancer. Thus, the down-regulation of NF-κB may be an exciting target in prevention and treatment of cancer. NF-κB could act as a tumor activator or tumor suppressant decided by ...
Development, characterization and antioxidant activity of polysorbate based O/W...
Khan, Barkat Ali; Akhtar, Naveed; Khan, Haroon; Braga, Valdir de AndradeThe objective of this study was to develop a pharmaceutical O/W emulsion containing plant-derived polyphenol extracts and evaluate its stability and antioxidant activity. O/W emulsions were prepared using ionic surfactant polysorbate 80 (Tween 80®). The odorwas adjusted with few drops of blue sea fragrance. DPPH (1,1-diphenyl-2-picrylhydrazyl) assay was used to evaluate the antioxidant activity of the plant ext...