4 documents found, page 1 of 1
May iron(III) complexes containing phenanthroline derivatives as ligands be pro...
Matos, Cristina P.; Adiguzel, Zelal; Yildizhan, Yasemin; Cevatemre, Buse; Onder, Tugba Bagci; Cevik, Ozge; Nunes, Patrique; Ferreira, Liliana P.Made available in DSpace on 2019-10-06T17:10:16Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-08-15; Fundação para a Ciência e a Tecnologia; We report the design, synthesis and biological studies on a group of mixed ligand Fe(III) complexes as anti-cancer drug candidates, namely their interaction with DNA, cytotoxicity and mechanism(s) of action. The aim is to obtain stable, efficient and selective Fe-...
Exploring the cytotoxic activity of new phenanthroline salicylaldimine Zn(II) c...
Matos, Cristina P.; Addis, Yemataw; Nunes, Patrique; Barroso, Sonia; Alho, Irina; Martins, Marta; Matos, Antonio P. A.; Marques, FernandaZinc(II) complexes bearing N-salicylideneglycinate (Sal-Gly) and 1,10-phenanthroline (phen) or phenanthroline derivatives [NN= 5-chloro-1,10-phenanthroline, 5-amine-1,10-phenanthroline (amphen), 4,7-diphenyl-1,10-phenanthroline (Bphen) and 5,6-epoxy-5,6-dihydro-1,10-phenanthroline] are synthesized. Complexes formulated as [Zn(NN)(2)(H2O)(2)](2+) (NN = phen and amphen), are also prepared. The cytotoxicity of the...
Evaluation of the binding of four anti-tumor Casiopeinas to human serum albumin
Correia, Isabel; Borovic, Sladjana; Cavaco, Isabel; Matos, Cristina P.; Roy, Somnath; Santos, Hugo M.; Fernandes, Luz; Capelo, Jose L.The metal complexes designated by Casiopeinas (R) are mixed-ligand Cu-II-compounds some of them having promising antineoplastic properties. We report studies of binding of Cu(glycinato)(4,7-dimethyl-1,10-phenanthroline) (Cas-II-Gly (1)), Cu(acetylacetonato)(4,7-dimethy1-1,10-phenanthroline) (Cas-III-Ea (2)), Cu(glycinato) (4,4'-dimethyl-2,2'-bipyridine) (Cas-W-Gly (3)) and Cu(acetylacetonato)(4,4'-dimethyl-2,2'...
Synthesis, structural characterization and leishmanicidal activity evaluation o...
Quintal, Susana; Morais, Tânia S.; Matos, Cristina P.; Robalo, Maria Paula; Piedade, M. Fátima M.; Brito, Maria J. Villa de; Garcia, M. HelenaNew ferrocenyl derivatives with the general formula FcC(O)L [Fc = (eta(5)-C5H5)Fe(eta(5)-C5H4)], where L is an aminoquinoline or hydroxyaminoquinoline, have been synthesized for evaluation of their leishmanicidal properties. The compounds were designed with ferrocene coupled to the quinolines by an amide or ester bridge. Ferrocenyl component is intended to act as quinoline carrier and ROS producer after in vivo...