4 documents found, page 1 of 1
CDH1 methylation in peritoneal washes as a prognostic factor for gastric cancer
Oliveira, Ana Carolina Favacho Miranda de; Modesto, Antonio André Conde; Moreira, Fabiano Cordeiro; Araújo, Taíssa Maíra ThomazGastric cancer is a major public health problem, considered the fifth most frequently diagnosed cancer worldwide. Peritoneal metastasis is the main causes of mortality related to gastric cancer. The hypermethylation of tumor suppressors genes is a promising factor for the development of predictive biomarkers. In gastric tumors, reduced expression of CDH1 suppressor gene contributes to tumor invasion and trigger...
Synthesis and biological evaluation of chalcones and derivatives in vitro again...
Anjos, Maricelia Lopes dos; Reis, Herald Souza dos; Bitencourt , Heriberto Rodrigues; Galucio, Natasha Costa da Rocha; Khayat, André SalimThe interest in obtaining chalcones is due to the numerous pharmacological activities described in the literature for these compounds that are intermediates in the biosynthesis of flavonoids. Thus, the synthesis and characterization of several chalcones and derivatives become important for the development of compounds with antiproliferative activity. In this work, ten substances were synthesized, seven chalcone...
Kinase inhibition in relapsed/refractory leukemia and lymphoma settings: recent...
Machado, Caio Bezerra; Pessoa, Flávia Melo Cunha de Pinho; Silva, Emerson Lucena da; Pantoja, Laudreísa da Costa; Ribeiro, Rodrigo MonteiroCancer is still a major barrier to life expectancy increase worldwide, and hematologic neoplasms represent a relevant percentage of cancer incidence rates. Tumor dependence of continuous proliferative signals mediated through protein kinases overexpression instigated increased strategies of kinase inhibition in the oncologic practice over the last couple decades, and in this review, we focused our discussion on...
Occurrence of Helicobacter pylori and Epstein-Barr virus infection in endoscopi...
Souza, Carolina Rosal Teixeira de; Oliveira, Kátia Soares de; Ferraz, Jefferson José Sodré; Leal, Mariana Ferreira; Calcagno, Danielle QueirozBackground: Helicobacter pylori (HP) and Epstein-Barr virus (EBV) have been associated with cancer development. We evaluated the prevalence of HP, HP CagA+ and EBV infection in gastric cancer (GC) samples from adults and in gastric tissues from patients who underwent upper endoscopy (UE). Methods: Samples from UE and GC were collected to investigate the presence of HP infection and the HP virulence factor CagA ...