22 documents found, page 1 of 3
High Instantaneous Inhibitory Potential of Bictegravir and the New Spiro-β-Lact...
Bártolo, Inês; Moura, Ines; Gonçalves, Paloma; Diniz, Ana Rita; Borrego, Pedro; Martin, Francisco; Figueiredo, Inês; Gomes, PerpétuaIntegrase inhibitors (INIs) are an important class of drugs for treating HIV-2 infection,given the limited number of drugs active against this virus. While the clinical efficacy of raltegravirand dolutegravir is well established, the clinical efficacy of bictegravir for treating HIV-2 infected patients has not been determined. Little information is available regarding the activity of bictegravir against HIV-2 i...
High Instantaneous Inhibitory Potential of Bictegravir and the New Spiro-ß-Lact...
Bártolo, Inês; Moranguinho, Inês; Gonçalves, Paloma; Ana Rita Diniz; Borrego, Pedro; Martin, Francisco; Figueiredo, Inês; Gomes, PerpetuaIntegrase inhibitors (INIs) are an important class of drugs for treating HIV-2 infection, given the limited number of drugs active against this virus. While the clinical efficacy of raltegravir and dolutegravir is well established, the clinical efficacy of bictegravir for treating HIV-2 infected patients has not been determined. Little information is available regarding the activity of bictegravir against HIV-2...
High instantaneous inhibitory potential of Bictegravir and the new Spiro-β-Lact...
Bártolo, Inês; Moranguinho, Inês; Gonçalves, Paloma; Diniz, Ana Rita; Borrego, Pedro; Martin, Francisco; Figueiredo, Inês; Gomes, PerpétuaIntegrase inhibitors (INIs) are an important class of drugs for treating HIV-2 infection, given the limited number of drugs active against this virus. While the clinical efficacy of raltegravir and dolutegravir is well established, the clinical efficacy of bictegravir for treating HIV-2 infected patients has not been determined. Little information is available regarding the activity of bictegravir against HIV-2...
The incidence of dental caries in children with Down Syndrome : a systematic re...
Martins, Mariana; Mascarenhas, Paulo; Evangelista, José Grillo; Barahona, Isabel; Tavares, VítorScientific evidence regarding the incidence of dental caries in Down syndrome (DS) patients is limited and sometimes presents divergent opinions among authors, making it difficult to reach definitive conclusions. We aimed to evaluate the caries incidence in the DS pediatric population and compare it against healthy controls. The search was performed using 4 universal databases: Cochrane, B-on, Biomed, and PubMe...
HIV Vif protein in docetaxel treatment of breast cancer cells
Cipriano, Pedro; Bandarra, Susana; Gonçalves, João; Ribeiro, Ana Clara; Barahona, Isabel
Effect of Vif in doxorubicin treated breast cancer cells
Bandarra, Susana; Cipriano, Pedro; Gonçalves, João; Ribeiro, Ana Clara; Barahona, Isabel
Characterization of CYP2C19*17 polymorphism in a Portuguese population sample r...
Ferraz, Adriana M. L.; Bandarra, Susana; Mascarenhas, Paulo; Barahona, Isabel; Martins, Rui; Ribeiro, Ana ClaraThe interindividual variability of Proton Pump Inhibitor (PPI) therapy results from the phenotype variability associated with the cytochrome P450 2C19 (CYP2C19) gene, namely the CYP2C19*17 allele. Our aim was to characterize patients’ genetic variability undergoing PPI therapy. A sample of 33 oral mucosa cells from Portuguese pharmacy patients was collected, followed by genotyping. The allelic frequencies of CY...
Cytotoxicity of temperature-responsive cationic diblock copolymers in human can...
Bandarra, Susana; Mascarenhas, Paulo; Barahona, Isabel; Nyströmb, Bo; Calejo, Maria Teresa
Evaluation of the cytotoxic potential of adhesives, with two on the market: Sco...
Santos, Sofia; Mascarenhas, Paulo; Bandarra, Susana; Ribeiro, Ana Clara; Maurício, Paulo; Barahona, IsabelIn vitro studies evaluating the cytotoxic potential of substances released from dental adhesives are lacking. The purpose of this study was to compare the cytotoxicity of the extracts of dental adhesives Scotchbond Universal and Optibond Solo Plus, and an adhesive in the experimental phase: T1. 3T3 mouse fibroblast cells and MG-63 osteoblast-like cells from human osteosarcoma were exposed for 24 h to serial ext...
Comparison of in-office and at-home tooth-whitening products cytotoxicity
Pitz, Kristel; Bandarra, Susana; Mascarenhas, Paulo; Ribeiro, Ana Clara; Azul, Ana; Salema-Oom, Madalena; Barahona, Isabel