17 documents found, page 1 of 2
Interstitial Lung Disease in Mixed Connective Tissue Disease: A Single-Center C...
Direndra Hasmucrai, Khea; Costa, Filipa; Sopa, Inês; Khmelinskii, Nikita; Fonseca, João Eurico; Boleto, GonçaloBACKGROUND: Mixed connective tissue disease is a rare systemic autoimmune condition characterized by overlapping features of different connective tissue diseases and the presence of anti-U1-ribonucleoprotein antibodies. Its association with interstitial lung disease represents one of the main causes of morbidity and mortality in affected patients. OBJECTIVE: To characterize the clinical, immunological, and radi...
Frequency, characteristics and predictors oc central and peripheral neurologica...
Costa, R. Pereira da; Bandeira, Matilde; Silvério-António, Manuel; Lopes, Ana Rita; Santos, Filipe Cunha; Pereira, Paulo J.; Raimundo, Diana BelchiorBackground: Sjogren's disease (SjD) systemic affection is being increasingly recognized. The prevalence of peripheral (PNS) and central (CNS) nervous system involvement in SjD and risk factors for these manifestations have not been clearly established. Objectives: To define the clinical characteristics of SjD patients with CNS and/or PNS involvement and to find predictors of this involvement.
PORTRESS – the PORTuguese Reuma.pt registry for Sjögren’S disease
Bandeira, Matilde; Silvério-António, Manuel; Costa, Roberto Pereira da; Lopes, Ana Rita; Santos, Filipe Cunha; Pereira, Paulo J.Aims: Sjögren's disease (SjD) is a complex disease with a wide variety of manifestations and outcomes. We recently created PORTRESS, the Portuguese SjD registry within Reuma.pt. We aim to describe this registry and characterize our national cohort. Methods: We included patients with a clinical diagnosis of SjD, registered in PORTRESS up to November 2023. Demographic, clinical, treatment, and patient-reported ou...
Anxiety and depression in patients with giant cell arteritis
Martinho, Joana Martins; Ponte, André; Dourado, Eduardo; Khmelinskii, Nikita; Barreira, Sofia C.; Machado, Ana R. Cruz; Macieira, Carla; Teixeira, VítorObjectives To compare the prevalence of anxiety and depression in patients with GCA with that in the general population, using the Hospital Anxiety and Depression Scale (HADS), and to identify independent predictors of these psychiatric manifestations in patients with GCA.Methods We conducted a cross-sectional study including all patients diagnosed with GCA followed during 1 year in a vasculitis outpatient clin...
ERN ReCONNET points to consider for treating patients living with autoimmune rh...
Talarico, Rosaria; Ramirez, Giuseppe Alvise; Barreira, Sofia; Cardamone, Chiara; Triggianese, Paola; Aguilera, Silvia; Andersen, Jeanette; Avcin, TadejRecent studies have shown that people who are immunocompromised may inadvertently play a role in spurring the mutations of the virus that create new variants. This is because some immunocompromised individuals remain at risk of getting COVID-19 despite vaccination, experience more severe disease, are susceptible to being chronically infected and remain contagious for longer if they become infected and consideri...
Efficacy of intravenous immunoglobulin in shrinking lung syndrome associated wi...
António, Manuel; Khmelinskii, Nikita; Fonseca, João EuricoShrinking lung syndrome is a rare manifestation of connective tissue diseases, namely systemic lupus erythematosus. It is characterised by reduced lung volumes and extra-pulmonary restrictive ventilatory pattern with good response to high-dose glucocorticoids alone or in combination with a second immunosuppressive agent. Here, we describe a case associated with mixed connective tissue disease and effectively tr...
SARS-CoV-2 outbreak in immune-mediated inflammatory diseases: the Euro-COVIMID ...
Saadoun, David; Vieira, Matheus; Vautier, Mathieu; Baraliakos, Xenofon; Andreica, Ioana; Silva, José A. P. da; Sousa, Marlene; Luís, MarianaBackground The COVID-19 pandemic has raised numerous questions among patients with immune-mediated inflammatory diseases regarding potential reciprocal effects of COVID-19 and their underlying disease, and potential effects of immunomodulatory therapy on outcomes related to COVID-19. The seroprevalence of SARS-CoV-2 and factors associated with symptomatic COVID-19 in patients with immune-mediated inflammatory d...
Localized forms of Vasculitis
Martins Martinho, Joana; Dourado, Eduardo; Khmelinskii, Nikita; Espinosa, Pablo; Ponte, CristinaPurpose of review: To provide an updated review on epidemiology, clinical manifestations, diagnostic assessment, treatment, and prognosis of localized vasculitis, following the 2012 Revised International Chapel Hill Consensus Conference Nomenclature on single-organ vasculitis. Recent findings: Localized, single-organ vasculitides encompass a group of rare conditions in which there is no evidence of concomitant ...
Gastric adenocarcinoma presenting as a rheumatoid factor and anti-cyclic citrul...
Silvério-António, Manuel; Parlato, Federica; Martins, Patrícia; Khmelinskii, Nikita; Braz, Sandra; Fonseca, João Eurico; Polido Pereira, JoaquimA 64-year-old male presented with a 6-month history of symmetric polyarthritis involving proximal interphalangeal joints and metacarpophalangeal joints of the hands, wrists, and ankles. Associated symptoms included vomiting, progressive fatigue, and weight loss. Laboratory results showed microcytic anemia, leukocytosis, thrombocytosis, elevated C-reactive protein and erythrocyte sedimentation rate, and rheumato...
Ultrasound halo sign as a potential monitoring tool for patients with giant cel...
Ponte, Cristina; Monti, Sara; Scirè, Carlo Alberto; Delvino, Paolo; Khmelinskii, Nikita; Milanesi, Alessandra; Teixeira, Vítor; Brandolino, FabioObjectives: To assess the sensitivity to change of ultrasound halo features and their association with disease activity and glucocorticoid (GC) treatment in patients with newly diagnosed giant cell arteritis (GCA). Methods: Prospective study of patients with ultrasound-confirmed GCA who underwent serial ultrasound assessments of the temporal artery (TA) and axillary artery (AX) at fixed time points. The number ...