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Development of an immobilization system for in situ micronutrients release
Ramos, Philippe Emmanuel Cruz; Cerqueira, Miguel Ângelo Parente Ribeiro; Cook, Michael T.; Bourbon, Ana Isabel Juncá Sottomayor LisboaAn immobilization system constituted by coated microcapsules was developed aiming at immobilizing probiotic bacteria capable of producing folate and release it in a sustained manner into the intestine. Despite no probiotic folate-producers have been immobilized so far, the system has been developed with this goal and this work reports its stability and ability to release folate under gastro-intestinal condition...
Layer-by-layer microcarrier production and characterization as a model to probi...
Ramos, Philippe E.; Cerqueira, Miguel Ângelo Parente Ribeiro; Cook, Michael; Charalampopoulos, Dimitris; Khutoryanskiy, Vitaliy V.; Teixeira, J. A.The recommended daily intake of folate (B-complex vitamin) for an adult varies between 200 and 400 g, being the intake of folate inefficient due its extremely unstable chemical forms. One of the presented solutions is the in situ production using probiotics. However, two concerns exist for this solution: a) probiotic bacteria may need protection towards the gastric medium (encapsulation); and b) microcapsule si...