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Transgenic adenocarcinoma of the mouse prostate (TRAMP) mode l : a good alterna...
Kido, Larissa Akemi, 1988-; Lamas, Celina de Almeida, 1990-; Maróstica Junior, Mário Roberto, 1980-; Cagnon, Valéria Helena Alves, 1967-Abstract: The use of genetically modified animals has been studied in scientific research over time as a way to discover new treatments or even a cure for various diseases. Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP) is a model for prostate cancer (PCa) that develops lesions that range from preneoplastic to metastasis. Its similarity to human PCa brings essential knowledge about disease development ...
Anti-inflammatory therapies in TRAMP mice: delay in PCa progression
Kido, Larissa Akemi, 1988-; Montico, Fabio, 1987-; Silva, Rafael Sauce, 1990-; Macedo, Aline Barbosa, 1986-; Minatel, Elaine, 1976-Abstract: The aim of this study was to characterize the structural and molecular biology as well as evaluate the immediate and late responses of prostatic cancer in the transgenic adenocarcinoma of the mouse prostate (TRAMP) model after treatment with goniothalamin (GTN) and celecoxib. The treated mice received GTN (150 mg/kg, gavage) or celecoxib (10 mg/kg, gavage) from 8 to 12 weeks of age. They were killed a...
Terapias antiangiogênicas, uso de Finasterida e resposta hormonal na próstata d...
Kido, Larissa Akemi, 1988-Orientador: Valéria Helena Alves Cagnon Quitete; Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia; Resumo: A senescência está associada a mudanças significativas no ambiente hormonal, sendo fator causador de alterações morfofuncionais na próstata. Os diferentes processos biológicos que ocorrem na próstata são regulados por polipeptídeos, dentre esses os fatores de crescimento do...