6 documents found, page 1 of 1
Effects and Mechanisms of Action of Preussin, a Marine Fungal Metabolite, again...
Seabra, R; Malhão, F; Correia, A; Costa, C; Kijjoa, A; Rocha, ETriple-negative breast cancer (TNBC) represents an aggressive subtype of breast cancer (BC) with a typically poorer prognosis than other subtypes of BC and limited therapeutic options. Therefore, new drugs would be particularly welcome to help treat TNBC. Preussin, isolated from the marine sponge-associated fungus, Aspergillus candidus, has shown the potential to reduce cell viability and proliferation as well ...
Determination of the absolute configuration of bioactive indole-containing pyra...
Long, S; Furlani, IL; Oliveira, JM; Resende, DISP; Silva, AMS; Gales, L; Pereira, JA; Kijjoa, A; Cass, QB; Oliveira, RV; Sousa, E; Pinto, MMMIn recent decades, fungi-derived naturally occurring quinazolines have emerged as potential drug candidates. Nevertheless, most studies are conducted for bioactivity assays, and little is known about their absorption, distribution, metabolism, and elimination (ADME) properties. To perform metabolic studies, the synthesis of the naturally occurring quinazolinone, fiscalin B (1), and its chloro derivative, 4-((1H...
Synthesis of new proteomimetic quinazolinone alkaloids and evaluation of their ...
Long, S; Resende, D; Kijjoa, A; Silva, A; Fernandes, R; Xavier, CPR; Vasconcelos, MH; Sousa, E; Pinto, MNew quinazolinone derivatives of the marine-derived alkaloids fiscalin B (3) and fumiquinazoline G (1), with neuroprotective and antitumor effects, were synthesized. Eleven quinazolinone-containing indole alkaloids were synthesized, proceeding the anti analogs via a one-pot method, and the syn analogs by the Mazurkiewicz-Ganesan approach. The neuroprotection capacity of these compounds on the rotenone-damage hu...
Erubescensoic Acid, a new polyketide and a xanthonopyrone SPF-3059-26 From the ...
Kumla, D; Dethoup, T; Gales, L; Pereira, J; Freitas-Silva, J; Costa, P; Silva, A; Pinto, M; Kijjoa, AA new polyketide erubescensoic acid (1), and the previously reported xanthonopyrone, SPF-3059-26 (2), were isolated from the uninvestigated fractions of the ethyl acetate crude extract of the marine sponge-associated fungus Penicillium erubescens KUFA0220. The structures of the new compound, erubescensoic acid (1), and the previously reported SPF-3059-26 (2), were elucidated by extensive analysis of 1D and 2D-N...
Chemistry of the fumiquinazolines and structurally related alkaloids
Resende, D.I.S.P; Boonpothong, P; Sousa, E; Kijjoa, A; Pinto M.M.M.Covering: this review covers the literature from 1992 to 2018 To date, approximately 80 naturally-occurring secondary metabolites which are structurally-related to fumiquinazolines have been isolated, mainly from marine sources. These alkaloids can be classified into twelve different groups and exhibit different structure motifs depending on the amino acids from which they are derived. This review is focused on...
Phycobiliproteins from cyanobacteria: Chemistry and biotechnological applications
Pagels, F; Guedes, A.C; Amaro, H.M; Kijjoa, A; Vasconcelos, V.Phycobiliproteinsareagroupofwatersolubleproteinswithanassociatedchromophore,responsibleforthelight-harvestingincyanobacteria.Theyaredividedinfourmaintypes:phycoerythrin,phycocyanin,phycoer-ythrocyanin and allophycocyanin, and they are characterized according to their structure and light qualityabsorption.Phycobiliproteinsfromcyanobacteriahavebeendescribedaspotentialbioactivecompounds,andrecognizedashigh-valuedn...