10 documents found, page 1 of 1
Monoterpene hydroxy lactones isolated from Thalassiosira sp. microalga and thei...
Morais, Alcina M. M. B.; Kumla, Decha; Martins, Valter F. R.; Alves, Ana; Gales, Luis; Silva, Artur M. S.; Costa, Paulo M.; Mistry, SharadTwo monoterpenoid lactones, loliolide (1) and epi-loliolide (2), were isolated from the crude dichloromethane extract of a microalga, Thalassiosira sp.). The structures of loliolide (1) and epi-loliolide (2) were elucidated by 1D and 2D NMR analysis, as well as a comparison of their 1H or/and 13C NMR data with those reported in the literature. In the case of loliolide (1), the absolute configurations of its ste...
Effects and Mechanisms of Action of Preussin, a Marine Fungal Metabolite, again...
Seabra, Rosária; Malhão, Fernanda; Correia, Alexandra; Costa, Carla; Kijjoa, Anake; Rocha, EduardoTriple-negative breast cancer (TNBC) represents an aggressive subtype of breast cancer (BC) with a typically poorer prognosis than other subtypes of BC and limited therapeutic options. Therefore, new drugs would be particularly welcome to help treat TNBC. Preussin, isolated from the marine sponge-associated fungus, Aspergillus candidus, has shown the potential to reduce cell viability and proliferation as well ...
Improving agar properties of farmed Gracilaria gracilis by using filtered sunlight
Silva-Brito, Francisca; Pereira, Sara Gonçalves; Rocha, Cristina M. R.; da Costa, Elisabete; Domingues, M. Rosário; Azevedo, Andreina; Kijjoa, AnakeThe effects of different light spectra on agar yield, composition and gel properties, pigment content and antioxidant activity of Gracilaria gracilis cultivated in a land-based IMTA-system were investigated. Total phenol content, antiradical activity and lipid peroxidation inhibitory capacity in the residue obtained from G. gracilis agar extraction (agar waste, AW) were also investigated. Gracilaria gracilis wa...
Neofiscalin A and fiscalin C are potential novel indole alkaloid alternatives f...
Bessa, Lucinda J.; Buttachon, Suradet; Dethoup, Tida; Martins, Rosario; Vasconcelos, Vitor; Kijjoa, Anake; Martins da Costa, PauloTen indole alkaloids were obtained from the marine sponge-associated fungus Neosartorya siamensis KUFA 0017. We studied the antimicrobial properties of these and of three other compounds previously isolated from the soil fungus N. siamensis KUFC 6349. Only neofiscalin A showed antimicrobial activity against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resis...
Chemical study and biological activity evaluation of two Azorean Macroalgae: Ul...
Silva, Madalena; Vieira, Luís M.; Almeida, Ana Paula; Silva, Artur M. S.; Seca, Ana M. L.; Barreto, Maria do Carmo; Neto, Ana I.; Pedro, MadalenaThe green macroalga Ulva rigida C. Agardh (Chlorophyta) and the red macroalga Gelidium microdon Kützing (Rhodophyta), collected from the Azorean archipelago, were investigated for their secondary metabolites and their in vitro growth inhibitory effect on three human tumor cell lines: MCF-7 (breast adenocarcinoma), NCI-H460 (non-small cell lung cancer) and A375-C5 (melanoma), as well as for their antifungal and ...
Cytotoxic meroterpenoids from the macroalga Cystoseira abies-marina
Gouveia, Vera L. M.; Seca, Ana M. L.; Barreto, Maria do Carmo; Neto, Ana I.; Kijjoa, Anake; Silva, Artur M. S.Two new meronorsesquiterpenes (cystoazorones A and B) and two new meroditerpenes (cystoazorols A and B), along with benzoic acid were isolated from the brown macroalga Cystoseira abies-marina. The structures of the new compounds were established by 1D and 2D NMR as well as HRMS spectral analysis. The in vitro cytotoxicity and antioxidant activity of the isolated compounds were also evaluated. Cystoazorones A an...
Valuable compounds on conifers, macroalgae and halophyte species
Isca, Vera M. S.; Gouveia, Vera F.; Seca, Ana M. L.; Barreto, Maria do Carmo; Pinto, Diana C. G. A.; Silva, Artur M. S.; Kijjoa, AnakeAs part of our on-going investigation on bioactive secondary metabolites, we carried out the phytochemical study of the endemic conifer Juniperus brevifolia and the macroalga Cystoseira abies-marine from Azores Islands, and also of the halophyte Salicornia ramosissima from Aveiro lagoon. This communication gives an overview on the isolation, structural characterization and bioactivity of the most interesting se...
Chemical and biological studies from an Azorean macroalga: Ulva rigida
Silva, Madalena; Vieira, Luís M. M.; Almeida, Ana Paula; Silva, Artur M. S.; Kijjoa, Anake; Seca, Ana M. L.; Barreto, Maria do CarmoNew drugs from natural sources have been targets of the drug discovery program and some bioactive compounds from macroalgae such as sulfated polysaccharides, steroids and diterpens have found their applications in the pharmaceutical industry.[1,2] Consequently, we have investigated the chemical composition and the in vitro antitumor potential of the metabolites isolated from the macroalga Ulva rigida, collected...
Bioactive meroditerpenes from Cystoseira abies-marina, collected from the coast...
Gouveia, Vera L. M.; Seca, Ana M. L.; Barreto, Maria do Carmo; Silva, Artur M. S.; Kijjoa, AnakeMany substances isolated from marine organisms have demonstrated to possess interesting biological and pharmacological activities and have been used as leads in the development of new pharmaceutical agents. Marine macroalgae are abundant and structuring organisms of the coastal area of all the islands in the Azores Archipelago; some have a markedly seasonal pattern and others are perennial and present during th...
Purification and structural characterization of compounds isolated from Cystose...
Gouveia, Vera L. M.; Seca, Ana M. L.; Barreto, Maria do Carmo; Silva, Artur M. S.; Kijjoa, AnakeAlthough the Azores archipelago is rich in algal communities, only two papers have been published concerning the nutritional and pharmacological potential of this resource in the Azorean sea.[4,5,6] As a brown alga Cystoseira abies-marina grows abundantly in the coast of these islands and has a great resistance to predation, which indicates the presence of potential active compounds[7], we have investigated its...