3 documents found, page 1 of 1
Effect of Quorum Sensing Molecule Farnesol on Mixed Biofilms of Candida albican...
Gaálová-Radochová, Barbora; Kendra, Samuel; Jordao, Luisa; Kursawe, Laura; Kikhney, Judith; Moter, Annette; Bujdáková, HelenaThe natural bioactive molecule farnesol (FAR) is widely studied mainly for its antibiofilm and antimicrobial properties. In addition, it increases the effectiveness of some antimicrobial substances, which makes it interesting for the development of combined therapy. In the present work, the effect of FAR either alone or in combination with oxacillin (OXA) on mixed biofilms formed by clinically relevant pathogen...
Evaluating efficacy of antimicrobial and antifouling materials for urinary trac...
Ramstedt, Madeleine; Ribeiro, Isabel A.C.; Bujdakova, Helena; Mergulhão, Filipe J.M.; Jordao, Luisa; Thomsen, Peter; Alm, Martin; Burmølle, MetteIn Europe, the mean incidence of urinary tract infections in intensive care units is 1.1 per 1000 patient-days. Of these cases, catheter-associated urinary tract infections (CAUTI) account for 98%. In total, CAUTI in hospitals is estimated to give additional health-care costs of £1-2.5 billion in the United Kingdom alone. This is in sharp contrast to the low cost of urinary catheters and emphasizes the need for...
Acrylic microparticles increase daptomycin intracellular and in vivo anti-biofi...
Woischnig, Anne Kathrin; Gonçalves, Lidia M.; Ferreira, Maxime; Kuehl, Richard; Kikhney, Judith; Moter, Annette; Ribeiro, Isabel A. C.Daptomycin (DAP) is a cyclic lipopeptide antibiotic with potential clinical application in orthopedic infections caused by staphylococci. However, it failed to eradicate Staphylococcus aureus in vitro, in intracellular infection studies, as well as in vivo in an experimental model of implant-associated biofilm infections. In this study, the antimicrobial effect of DAP encapsulated in poly(methyl methacrylate)-E...