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Clinical, histological and molecular profiling of different stages of alcohol-r...

Ventura-Cots, Meritxell; Argemi, Josepmaria; Jones, Patricia D; Lackner, Carolin; El Hag, Mohamed; Abraldes, Juan G; Alvarado, Edilmar; Clemente, Ana

Objective: Alcohol-related liver disease (ALD) ranges from never-decompensated ALD (ndALD) to the life-threatening decompensated phenotype, known as alcohol-related hepatitis (AH). A multidimensional study of the clinical, histological and molecular features of these subtypes is lacking. Design: Two large cohorts of patients were recruited in an international, observational multicentre study: a retrospective co...


Alcohol-related liver disease is rarely detected at early stages compared with ...

Shah, Neil D.; Ventura-Cots, Meritxell; Abraldes, Juan G.; Alboraie, Mohamed; Alfadhli, Ahmad; Argemi, Josepmaria; Badia-Aranda, Ester

Background & aims: Despite recent advances in treatment of viral hepatitis, liver-related mortality is high, possibly owing to the large burden of advanced alcohol-related liver disease (ALD). We investigated whether patients with ALD are initially seen at later stages of disease development than patients with hepatitis C virus (HCV) infection or other etiologies. Methods: We performed a cross-sectional study o...


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