3 documents found, page 1 of 1
Peptides ToAP3 and ToAP4 decrease release of inflammatory cytokines through TLR...
Veloso Júnior, Paulo Henrique de Holanda; Simon, Karina Smidt; Castro, Raffael Júnio Araújo de; Coelho, Luísa Coutinho; Hurtado Erazo, Fabián AndresAntimicrobial peptides (AMPs) are small molecules with microbicidal and immunoregulatory activities. In this study we evaluated the anti-inflammatory and antimicrobial activities of peptides ToAP3 and ToAP4, AMPs from the venom of the Brazilian scorpion Tityus obscurus. To test the peptides’ activity, murine bone marrow-derived macrophages (BMDMs) or dendritic cells (BMDCs) were stimulated with peptides plus LP...
The activity of a Hexameric M17 Metallo-Aminopeptidase is associated with survi...
Corrêa, André França; Bastos, Izabela Marques Dourado; Neves, David; Kipnis, André; Kipnis, Ana Paula Junqueira; Santana, Jaime Martins deMycobacterium tuberculosis is one of the most prevalent human pathogens causing millions of deaths in the last years. Moreover, tuberculosis (TB) treatment has become increasingly challenging owing to the emergence of multidrug resistant M. tuberculosis strains. Thus, there is an immediate need for the development of new anti-TB drugs. Proteases appear to be a promising approach and may lead to shortened and ef...
Non-disulfide-Bridge peptide 5.5 from the Scorpion Hadrurus gertschi Inhibits t...
Trentini, Monalisa Martins; Neves, Rogério Coutinho das; Santos, Bruno de Paula Oliveira; Silva, Roosevelt Alves da; Souza, Adolfo CarlosMulti-drug resistant microorganisms have been a growing concern during the last decades due to their contribution in mortality rates worldwide. Antimicrobial peptides (AMPs) are broad spectrum antimicrobial agents that display potent microbicidal activity against a wide range of microorganisms. AMPs generally have a rapid mode of action that reduces the risk of resistance developing among pathogens. In this stu...