Made available in DSpace on 2022-04-29T08:39:28Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-01-01; Total synthesis of taiwanin C was realised efficiently in a global yield of 52%. Taiwanin C in aggregation assays inhibited platelet aggregation in a concentration-dependent manner with an IC50 of 0.46 μM after exposure of human platelet to AA. Similarly, to AA, taiwanin C inhibited significantly TRAP-6...
Made available in DSpace on 2020-12-10T16:35:56Z (GMT). No. of bitstreams: 0 Previous issue date: 2012-04-01; We characterized the nitric oxide (NO)-cyclic GMP-phosphodiesterase-5 (PDE5) pathway in Crotalus durissus terrificus aorta. Concentration responses curves to acetylcholine (ACh), sodium nitroprusside (SNP), BAY41-2272 (soluble guanylyl cyclase [sGC] stimulator), BAY60-2770 (sGC activator) and tadalafil ...
Made available in DSpace on 2020-12-12T02:38:20Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-06-01; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Background: Lorcaserin is an anti-obesity drug whose weight loss effect results from 5-hydroxytryptami...
Made available in DSpace on 2020-12-12T02:02:37Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-07-01; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); The role of endothelium in the electrical-field stimulation (EFS)-induced contractions of Chelonoidis ...
Made available in DSpace on 2019-10-06T15:47:16Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-09-05; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Mirabegron is the first β3-adrenoceptor agonist approved on the market and may offer beneficial pharmacological action in patients with overactive bladder and erectile dysfunction. Here, we further investigate the mechanisms by which mirabeg...
Made available in DSpace on 2018-12-11T16:46:26Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-04-01; Background: The aim of the present study was to evaluate different signaling pathways by which exercise training would interfere in endothelial function in obesity. Therefore, we examined adipocytokine levels and their receptors in the corpus cavernosum and femoral artery from trained rats on a high-fat...
Made available in DSpace on 2015-10-21T13:13:16Z (GMT). No. of bitstreams: 0 Previous issue date: 2015-03-15; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Aims: The importance of perivascular adipose tissue (PVAT) in vascular function has recently been recognized. The aim of the study was to investigate the effects of exercise training on anticontractile responses of periaortic adipose tissue....