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The senotherapeutic potential of phytochemicals for age-related intestinal disease

Costa, Célia Maria; Pedrosa, Sílvia Santos; Kirkland, James L; Reis, Flávio; Madureira, Raquel

During the last few decades, life expectancy has increased worldwide along with the prevalence of several age-related diseases. Among aging pathways, cellular senescence and chronic inflammation (or “inflammaging”) appear to be connected to gut homeostasis and dysbiosis of the microbiome. Cellular senescence is a state of essentially irreversible cell cycle arrest that occurs in response to stress. Although sen...


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