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Anti-Helicobacter pylori and Anti-inflammatory Properties of Eugenia uniflora L.
Monteiro,Jessica Raquel Borges; Ardisson,Juliana Santa; Athaydes,Brena Ramos; Gonçalves,Rita de Cássia Ribeiro; Rodrigues,Ricardo PereiraAbstract Helicobacter pylori is a bacterium that reaches half of the world population and it’s recognized as the main cause of chronic gastritis and peptic ulcer. In this study, we evaluated the anti-H. pylori, antioxidant and immunomodulatory activities of the methanolic (MeOH) extract of Eugenia uniflora leaves and chemical profile. Anti-H. pylori activity was evaluated by spectrophotometric broth microdiluti...
Preformulation study and influence of DMSO and propylene glycol on the antioxid...
Damasceno,João Paulo Loureiro; Giuberti,Cristiane dos Santos; Gonçalves,Rita de Cássia Ribeiro; Kitagawa,Rodrigo RezendeAbstractCoumarins are phenolic compounds and have various biological properties, including antioxidant activity. The isocoumarin paepalantine, isolated from of Paepalanthus bromelioides Silveira, Eriocaulaceae, exhibits a wide range of biological activities, including antimicrobial, anti-inflammatory, antioxidant and cytotoxic properties. Studies on paepalantine often use dimethylsulfoxide as a solvent. However...
Anti-Helicobacter pylori activity and oxidative burst inhibition by the naphtho...
Kitagawa,Rodrigo Rezende; Bonacorsi,Cibele; Fonseca,Luiz Marcos da; Vilegas,Wagner; Raddi,Maria Stella GonçalvesHelicobacter pylori is a bacterium recognized as the major cause of chronic gastritis and peptic ulcers. Infection by H. pylori induces inflammatory responses and pathological changes in the gastric microenvironment. The host Keywords: immune cells (especially neutrophils) release inflammatory mediators and large 5-methoxy-3,4-dehydroxanthomegnin amounts of reactive oxygen species (ROS), which are associated wi...
Antitumor and immunomodulatory effects of the naphthoquinone 5-methoxy-3,4-dehy...
Kitagawa,Rodrigo Rezende; Vilegas,Wagner; Carlos,Iracilda Zeppone; Raddi,Maria Stella GonçalvesLarge number of quinones has been associated with antitumor, antibacterial, antimalarial and antifungal activities. In this work we describe the effect of the naphthoquinone, 5-methoxy-3,4-dehydroxanthomegnin, on murine tumor cells (LP07 and LM2) and its immunomodulatory effect on nitric oxide (NO) production on LPS-stimulated macrophages. The results have shown that 5-methoxy-3,4-dehydroxanthomegnin was a sign...