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Levosimendan efficacy and safety : 20 Years of SIMDAX in clinical use

Papp, Zoltán; Agostoni, Piergiuseppe; Alvarez, Julian; Bettex, Dominique; Bouchez, Stefan; Brito, Dulce; Cˇerný, Vladimir; Comin-Colet, Josep

Levosimendan was first approved for clinical use in 2000, when authorization was granted by Swedish regulatory authorities for the hemodynamic stabilization of patients with acutely decompensated chronic heart failure (HF). In the ensuing 20 years, this distinctive inodilator, which enhances cardiac contractility through calcium sensitization and promotes vasodilatation through the opening of adenosine triphosp...

Date: 2020   |   Origin: Repositório da Universidade de Lisboa
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