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Nanoparticle carrier co-delivery of complementary antibiofilm drugs abrogates d...
Roncari Rocha, Guilherme [UNESP]; Sims, Kenneth R.; Xiao, Baixue; Klein, Marlise I. [UNESP]; Benoit, Danielle S.W.Made available in DSpace on 2022-04-28T19:47:44Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-01-01; Background: Dental caries is a multifactorial disease caused by pathogenic biofilm. In particular, Streptococcus mutans synthesizes biofilm exopolysaccharides, while Candida albicans is associated with the development of severe carious lesions. Aim: This study aimed to prevent the formation of S. mutans...
PH-Activated nanoparticles for controlled topical delivery of farnesol to disru...
Horev, Benjamin; Klein, Marlise I. [UNESP]; Hwang, Geelsu; Li, Yong; Kim, Dongyeop; Koo, Hyun; Benoit, Danielle S. W.Made available in DSpace on 2022-04-29T07:25:56Z (GMT). No. of bitstreams: 0 Previous issue date: 2015-03-24; Development of effective therapies to control oral biofilms is challenging, as topically introduced agents must avoid rapid clearance from biofilm-tooth interfaces while targeting biofilm microenvironments. Additionally, exopolysaccharides-matrix and acidification of biofilm microenvironments are associ...
Systematic approach to identify novel antimicrobial and antibiofilm molecules f...
Ribeiro, Sabrina M. [UNESP]; Fratucelli, Érick D. O. [UNESP]; Fernandes, Júlia M. [UNESP]; Bueno, Paula C. P. [UNESP]; Cavalheiro, Alberto José [UNESP]Made available in DSpace on 2021-06-25T10:59:52Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-03-01; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Natural products provide structurally different substances, with a myriad of biological activities. However, the identification and isolation of active compounds from plants are challenging because of the complex plant matrix and time-consum...
Modulation of lipoteichoic acids and exopolysaccharides prevents Streptococcus ...
Pedraza, Midian C. Castillo [UNESP]; De Oliveira Fratucelli, Erick Dante [UNESP]; Ribeiro, Sabrina Marcela [UNESP]Made available in DSpace on 2020-12-12T01:23:01Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-05-01; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Dental caries is a diet-biofilm-dependent disease. Streptococcus mutans contributes to cariogenic biofilms by producing an extracellular matrix rich in exopolysaccharides and acids. The study aimed to determine the effect of topical treatmen...
DNase increases the efficacy of antimicrobial photodynamic therapy on Candida a...
Panariello, Beatriz H.D. [UNESP]; Klein, Marlise I. [UNESP]; Alves, Fernanda [UNESP]; Pavarina, Ana Cláudia [UNESP]Made available in DSpace on 2019-10-06T17:11:09Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-09-01; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Antimicrobial Photodynamic Therapy (aPDT) has been proposed as a means to treat Candida infections. However, microorganisms in biofilms are less susceptible to aPDT than planktonic cultures, possibly because the matrix limits the penetration...
Inactivation of Streptococcus mutans genes lytST and dltAD impairs its pathogen...
Castillo Pedraza, Midian C. [UNESP]; Rosalen, Pedro L.; Castilho, Aline Rogéria Freire de; Freires, Irlan de Almeida; de Sales Leite, Luana [UNESP]Made available in DSpace on 2019-10-06T15:43:30Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-01-01; Background: Streptococcus mutans orchestrates the development of a biofilm that causes dental caries in the presence of dietary sucrose, and, in the bloodstream, S. mutans can cause systemic infections. The development of a cariogenic biofilm is dependent on the formation of an extracellular matrix rich...
Antimicrobial photodynamic therapy alone or in combination with antibiotic loca...
Tavares, Lívia J. [UNESP]; de Avila, Erica D. [UNESP]; Klein, Marlise I. [UNESP]; Panariello, Beatriz H.D.; Spolidório, Denise M.P. [UNESP]Made available in DSpace on 2019-10-06T15:57:22Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-11-01; Antimicrobial photodynamic therapy (aPDT) kills several planktonic pathogens. However, the susceptibility of biofilm-derived anaerobic bacteria to aPDT is poorly characterized. Here, we evaluated the effect of Photodithazine (PDZ)-mediated aPDT on Fusobacterium nucleatum and Porphyromonas gingivalis bio...
Inactivation of genes TEC1 and EFG1 in Candida albicans influences extracellula...
Dias Panariello, Beatriz Helena [UNESP]; Klein, Marlise I. [UNESP]; Pavarina, Ana Claudia [UNESP]; Duarte, SimoneMade available in DSpace on 2018-11-26T17:42:30Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-10-17; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Background: Infections caused by Candida spp. have been associated with formation of a biofilm, i.e. a complex microstructure of cells adhering to a surface and embedded w...
Effect of Twice-Daily Blue Light Treatment on Matrix-Rich Biofilm Development
Sousa, Denise Lins de; Lima, Ramille Araujo; Zanin, Iriana Carla; Klein, Marlise I. [UNESP]; Janal, Malvin N.; Duarte, SimoneMade available in DSpace on 2018-11-26T15:27:43Z (GMT). No. of bitstreams: 0 Previous issue date: 2015-07-31; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Background The use of blue light has been proposed as a direct means of affecting local bacterial infections, however the use of blue light without a photosensitizer to prevent the biofilm development has not yet been explored. The aim...
Fluconazole impacts the extracellular matrix of fluconazole-susceptible and -re...
Panariello, Beatriz Helena Dias; Klein, Marlise I. [UNESP]; Mima, Ewerton Garcia De Oliveira [UNESP]; Pavarina, Ana Cláudia [UNESP]Made available in DSpace on 2018-12-11T17:37:18Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-01-01; Made available in DSpace on 2018-12-11T17:37:18Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-01-01; Made available in DSpace on 2018-12-11T17:37:18Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-01-01; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de ...