2 documents found, page 1 of 1
The catechol-O-methyltransferase inhibitory potential of Z-vallesiachotamine by...
Passos,Carolina dos Santos; Klein-Júnior,Luiz Carlos; Andrade,Juliana Maria de Mello; Matté,Cristiane; Henriques,Amélia TeresinhaAbstractZ-Vallesiachotamine is a monoterpene indole alkaloid that has a β-N-acrylate group in its structure. This class of compounds has already been described in different Psychotriaspecies. Our research group observed that E/Z-vallesiachotamine exhibits a multifunctional feature, being able to inhibit targets related to neurodegeneration, such as monoamine oxidase A, sirtuins 1 and 2, and butyrylcholinesteras...
Validation of an hplc method for the determination of 1,7-dihydroxy-2,3-methyle...
Klein-Júnior,Luiz Carlos; Andrade,Sérgio Faloni de; Cechinel-Filho,Valdir; Bresolin,Tania Mari BelléPolygala cyparissias is a plant widespread in Southern Latin America. Recently, we demonstrated the gastroprotective activity of the extract, as well as for one of the isolated metabolites-1,7-dihydroxy-2,3-methylenedioxyxanthone (MDX). In this study, a HPLC method for the quantification of MDX was validated. The HPLC method was linear (0.5-24 µg mL-1 of MDX) with good accuracy, precision and robustness. The co...