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Literature Review on Single and Twin-Screw Extruders Design for Polymerization ...
Delvar, Elham; Oliveira, Inês; Brito, Margarida S. C. A.; Silva, Cláudia G.; Santamaria-Echart, Arantzazu; Barreiro, M.F.; Santos, Ricardo J.This work presents a comprehensive review of the evolution in modeling reactive extrusion (REx), tracing developments from early analytical models to advanced computational fluid dynamics (CFD) simulations. Additionally, it highlights the key challenges and future directions in this field. Analytical models to describe the velocity profiles were proposed in the 1950s, involving certain geometrical simplificatio...
Recent developments and challenges in the application of fungal laccase for the...
Magalhães, Flávia F.; Pereira, Ana F. S.; Cristóvão, Raquel O.; Barros, Rita A. M.; Faria, Joaquim L.; Silva, Cláudia G.; Freire, Mara G.According to the European Environment Agency, the textile industry is responsible for 20% of global water pollution due to dyeing and finishing products, thus facing severe environmental challenges. It is essential to design more biocompatible and sustainable treatment processes capable of removing dyes from industrial wastewater to fight this environmental hazard. Chemical industries must change traditional ch...
Multi-walled carbon nanotubes as a platform for Immunoglobulin G attachment
Almeida, Mafalda R.; Barros, Rita A.M.; Pereira, Matheus M.; Castro, Daniel; Faria, Joaquim L.; Freire, Mara G.; Silva, Cláudia G.; Tavares, Ana P.M.Nanomaterials have been extensively used in different applications due to their peculiar characteristics and nanoscale dimensions. Among nanoparticles, carbon-based nanomaterials are becoming highly attractive for biomedical applications such as diagnosis, tissue engineering, drug delivery, and biosensing. The conjugation of carbon-based nanomaterials with antibodies combines the properties of these materials w...
Superior operational stability of immobilized l-asparaginase over surface-modif...
Almeida, Mafalda R.; Cristóvão, Raquel O.; Barros, Maria A.; Nunes, João C. F.; Boaventura, Rui A. R.; Loureiro, José M.; Faria, Joaquim L.Made available in DSpace on 2022-04-28T19:46:42Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-12-01; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Fundação para a Ciência e a Tecnologia; l-asparaginase (ASNase, EC 3.5.1.1) is an enzyme that catalyzes the l-asparagine hydrolysis into l-aspartic acid and ammonia, being mainly applied in pharmaceutical and food industries. However, some d...
Biomedical-related applications of functionalized nanomaterials
Almeida, Mafalda R.; Neves, Márcia C.; Morales-Torres, Sergio; Freire, Mara G.; Faria, Joaquim L.; Santos-Ebinuma, Valéria C. [UNESP]; Silva, Cláudia G.Made available in DSpace on 2022-04-28T19:50:56Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-01-01; This chapter provides an overview of the use of nanoparticles in the biomedical field. Due to their unique properties, nanomaterials have enabled the development of innovative technologies within the biomedical field, making them a popular topic of research. Nanoparticles (NPs) can be prepared from a wi...
Carbon nanotubes for biomedical applications
Almeida, Mafalda R.; Nunes, João C. F.; Cristóvão, Raquel O.; Faria, Joaquim L.; Tavares, Ana P. M.; Silva, Cláudia G.; Freire, Mara G.Carbon nanotubes (CNTs) were discovered in 1991, and since then, have been one of the most intensely studied nanomaterials due to their improved functionalities and diversity of applications. Specifically, CNTs are entirely composed of carbon atoms connected through sp2 bonds structured in several condensed benzene rings rolled up into a cylinder form. Depending on the number of graphitic layers, CNTs can be cl...
Impact of atomic layer deposited TiO2 on the photocatalytic efficiency of TiO2/...
Oliveira, Inês; Silva, Ricardo M.; Rodrigues, Joana; Correia, Maria R.; Monteiro, Teresa; Faria, Joaquim L.; Silva, Rui F.; Silva, Cláudia G.Titanium oxide (TiO2) has been widely investigated as a photocatalytic material, and the fact that its performance depends on its crystalline structure motivates further research on the relationship between preparation methods and material properties. In this work, TiO2 thin films were grown on non- functionalized wave-like patterned vertically aligned carbon nanotubes (w-VA-CNTs) via the atomic layer depositio...
Immobilization and characterization of l-asparaginase over carbon xerogels
Barros, Rita A. M.; Cristóvão, Raquel O.; Carabineiro, Sónia A. C.; Neves, Márcia C.; Freire, Mara G.; Faria, Joaquim L.; Santos-Ebinuma, Valéria C.L-asparaginase (ASNase) is an aminohydrolase currently used in the pharmaceutical and food industries. Enzyme immobilization is an exciting option for both applications, allowing for a more straightforward recovery and increased stability. High surface area and customizable porosity make carbon xerogels (CXs) promising materials for ASNase immobilization. This work describes the influence of contact time, pH, a...
Unveiling the Influence of Carbon Nanotube Diameter and Surface Modification on...
Cristóvão, Raquel O.; Barros, Rita A. M.; Pinho, João G.; Teixeira, Lília S.; Neves, Márcia C.; Freire, Mara G.; Faria, Joaquim L.L-asparaginase (ASNase, EC 3.5.1.1) is an amidohydrolase enzyme known for its anti-cancer properties, with an ever-increasing commercial value. Immobilization has been studied to improve the enzyme’s efficiency, enabling its recovery and reuse, enhancing its stability and half-life time. In this work, the effect of pH, contact time and enzyme concentration during the ASNase physical adsorption onto pristine and...
L-asparaginase-based biosensors
Nunes, João C. F.; Cristóvão, Raquel O.; Santos-Ebinuma, Valéria C.; Faria, Joaquim L.; Silva, Cláudia G.; Neves, Márcia C.; Freire, Mara G.L-asparaginase (ASNase) is an aminohydrolase enzyme widely used in the pharmaceutical and food industries. Although currently its main applications are focused on the treatment of lymphoproliferative disorders such as acute lymphoblastic leukemia (ALL) and acrylamide reduction in starch-rich foods cooked at temperatures above 100 ºC, its use as a biosensor in the detection and monitoring of L-asparagine levels ...