4 documents found, page 1 of 1
Identification and Characterization of Myeloid-Derived Suppressor Cells (MDSC) ...
Rodrigues, Cátia F.; A. Rodrigues, Catarina; Maia, Patrícia; Sousa, M. Emília; Godinho, Inês; Neves, Bruno; Duarte, Iola; Lara Santos, LúcioIntroduction: Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells that accumulate under pathological conditions, such as cancer, and suppress immune responses through various mechanisms. Distinguishing MDSC populations remains challenging due to their shared surface markers with neutrophils and monocytes, complicating accurate identification and quantification. This...
Establishment of a Protocol for the Characterization of Secreted Biomolecules i...
Pires, Rita; Rodrigues, Lénia; Santos, Fátima; Duarte, Iola; Ciordia, Sérgio; Peixe, Augusto; Cardoso, HéliaSomatic embryogenesis (SE) involves the formation of embryo-like structures from somatic cells without fertilization and is widely used for clonal propagation and genetic transformation. However, in olive (Olea europaea sp. europaea), SE remains challenging due to the recalcitrant behavior of adult tissues when used as initial explants. Bioactive molecules released into the culture medium (conditioned medium, C...
PM2.5 chemical composition and health risks by inhalation near a chemical complex
Alves, Célia; Evtyugina, Margarita; Vicente, Estela; Vicente, Ana; Rienda, Ismael Casotti; Sánchez de la Campa, Ana; Tomé, Mário; Duarte, IolaParticulate matter (PM2.5) samples were collected in the vicinity of an industrial chemical pole and analysed for organic and elemental carbon (OC and EC), 47 trace elements and around 150 organic constituents. On average, OC and EC accounted for 25.2% and 11.4% of the PM2.5 mass, respectively. Organic compounds comprised polycyclic aromatic hydrocarbons (PAHs), alkylated PAHs, anhydrosugars, phenolics, aromati...
Remodeling of liver phospholipidomic profile in streptozotocin-induced diabetic...
Simoes, Claudia; Domingues, Pedro; Ferreira, Rita; Amado, Francisco; Duarte, Jose Alberto; Vitorino, Rui; Neuparth, Maria Joao; Nunes, ClaudiaLipid homeostasis in liver is known to be altered with diabetes mellitus, ultimately leading to liver damage and related complications. The present work aimed to evaluate changes in the liver phospholipid profile after 4 months of uncontrolled hyperglycemia. Twenty Wistar rats were divided into two groups: control and streptozotocin-treated (T1DM). After 4 months, animals were sacrificed and morphological chara...