4 documents found, page 1 of 1
Antimicrobial activity of a library of thioxanthones and their potential as eff...
Durães, F; Palmeira, A; Cruz, B; Freitas-Silva, J; Szemerédi, N; Gales, L; Costa, PM; Remião, F; Silva, R; Pinto, M; Spengler, G; Sousa, EThe overexpression of efflux pumps is one of the causes of multidrug resistance, which leads to the inefficacy of drugs. This plays a pivotal role in antimicrobial resistance, and the most notable pumps are the AcrAB-TolC system (AcrB belongs to the resistance-nodulation-division family) and the NorA, from the major facilitator superfamily. In bacteria, these structures can also favor virulence and adaptation m...
New efflux pumps inhibitors for Gram positive bacteria strains and cancer cells...
Ramalhete, Cátia; Spengler, G; Serley, J; Duarte, N; Viveiros, M; Amaral, L; Molnár, J; Mulhovo, S; Ferreira, MJUAll living cells contain genes encoding multidrug transporters and some of them play an important role in conferring drug resistance in mammalian cancer cells and in microbial pathogens such as Staphylococcus aureus, Enterococcus faecalis, Candida albicans, Plasmodium falciparum, and Leishmania donovani. The over-expression of P- glycoprotein (P-gp) is one of the principal mechanisms of multidrug resistance (MD...
New efflux pump inhibitors in Gram positive bacteria strains and cancer cells f...
Ramalhete, C; Spengler, G; Serly, J; Duarte, N; Mulhovo, S; Amaral, L; Molnár, J; Ferreira, MJU
Effect of cycloartanes on reversal of multidrug resistance and apoptosis induct...
Madureira, AM; Spengler, G; Molnar, A; Varga, A; Molnar, J; Abreu, PM; Ferreira, MJUThe ability of fifteen cycloartanes, isolated from Euphorbia species, to reverse multidrug resistance (MDR) and apoptosis induction in L5178Y mouse lymphoma cells, including its multidrug-resistant subline, was studied by flow cytometry. Reversion of MDR was investigated using a standard functional assay with rhodamine 123 as a fluorescent substrate analogue. For the evaluation of apoptosis, the cells were stai...