2 documents found, page 1 of 1
Aligned silk-based 3-D architectures for contact guidance in tissue engineering
Oliveira, A. L.; Sun, L.; Kim, H. J.; Rice, W.; Kluge, J.; Reis, R. L.; Kaplan, DavidAn important challenge in the biomaterials field is to mimic the structure of functional tissues via cell and extracellular matrix (ECM) alignment and anisotropy. Toward this goal, silk-based scaffolds resembling bone lamellar structure were developed using a freeze-drying technique. The structure could be controlled directly by solute concentration and freezing parameters, resulting in lamellar scaffolds with ...
Designing silk-based 3D architectures with controlled lamellar morphology
Oliveira, A. L.; Sun, L.; Kim, H. J.; Hu, X.; Rice, W.; Kluge, J.; Reis, R. L.; Kaplan, D. L.[Excerpt] The impressive mechanical properties, along with established biocompatibility and slow degradability, render silk as an interesting biomaterial for bone tissue engineering applications. New silk-based scaffolds resembling bone lamellar structure were successfully developed using a freeze-drying technique. The structure could be controlled directly by the solute concentration and freezing parameters. T...