8 documents found, page 1 of 1
ffect of resistance exercise training on blood antioxidant capacity in rats und...
Anjos, J; Santos, S; Anjos, L; Aires, I; Garcias, I; Azevedo, C; Silva, M; Oliveira, PA; Faustino-Rocha, Ana I; Peixoto, FIntroduction: Doxorubicin (DOX) is an efficient chemotherapeutic drug used in the treatment of several types of cancer, such as breast cancer. DOX causes cardiotoxicity that leads to cardiac inflammation and remodeling as a result of oxidative stress and impaired mitochondrial function. Several studies observed a beneficial effect of exercise training on antioxidants, due to upregulation of the activity of some...
Resistance exercise in an animal model of mammary cancer treated with doxorubic...
Anjos, L; Santos, S; Anjos, J; Aires, I; Garcias, I; Azevedo, C; Moreira-Gonçlaves, M; Ferreira, R; Duarte, JA; Oliveira, PA; Faustino-Rocha, Ana IIntroduction: Doxorubicin (DOX) is one of the most effective antitumor drugs for breast cancer treatment. DOX is associated to high toxicity in multiple organs and tissues. This study aimed to assess the effects of resistance exercise training (RET) in the hematological parameters of rats with mammary cancer treated with DOX. Material & Methods: Wistar Rats were divided into six groups: I (sedentary, SED), II (...
Effect of resistance exercise training on blood antioxidant capacity in rats un...
Anjos, J; Santos, SD; Anjos, L; Aires, I; Garcias, I; Azevedo, C; Silva, M; Oliveira, PA; Faustino-Rocha, AI; Peixoto, FIntroduction: Doxorubicin (DOX) is an efficient chemotherapeutic drug used in the treatment of several types of cancer, such as breast cancer. DOX causes cardiotoxicity that leads to cardiac inflammation and remodeling as a result of oxidative stress and impaired mitochondrial function. Several studies observed a beneficial effect of exercise training on antioxidants, due to upregulation of the activity of some...
Resistance exercise in an animal model of mammary cancer treated with doxorubic...
Anjos, L; Santos, SD; Anjos, J; Aires, I; Garcias, I; Azevedo, C; Gonçalves-Moreira, D; Ferreira, R; Duarte, JA; Oliveira, PA; Faustino-Rocha, AIIntroduction: Doxorubicin (DOX) is one of the most effective antitumor drugs for breast cancer treatment. DOX is associated to high toxicity in multiple organs and tissues. This study aimed to assess the effects of resistance exercise training (RET) in the hematological parameters of rats with mammary cancer treated with DOX. Material & Methods: Wistar Rats were divided into six groups: I (sedentary, SED), II (...
Value of simple otoscopy in diagnosing otitis media with effusion in children
Azevedo, C; Firmino Machado, J; Fontes Lima, A; Milhazes Mar, F; Vilarinho, S; Dias, LAims To explore the value of otoscopy in diagnosing OME when performed by otorhinolaryngology, pediatrics, and primary care physicians; to evaluate the interobserver and intraobserver agreement of interpretation of otoscopy images. Material and methods A cross-sectional study using an anonymous mailed survey was used. We presented pre-recorded otoscopy images of pediatric patients to otorhinolaryngology, pediat...
An intact C-terminal end of albumin is required for its long half-life in humans
Nilsen, J; Trabjerg, E; Grevys, A; Azevedo, C; Brennan, SO; Stensland, M; Wilson, J; Sand, KMK; Bern, M; Dalhus, B; Roopenian, DC; Sandlie, I; Rand, KDAlbumin has an average plasma half-life of three weeks and is thus an attractive carrier to improve the pharmacokinetics of fused therapeutics. The half-life is regulated by FcRn, a cellular receptor that protects against intracellular degradation. To tailor-design the therapeutic use of albumin, it is crucial to understand how structural alterations in albumin affect FcRn binding and transport properties. In t...
Molecular Responses of Mussel Mytilus galloprovincialis Associated to Accumulat...
Martins, JC; Domínguez-Pérez, D; Azevedo, C; Braga, AC; Costa, PR; Osorio, H; Vasconcelos, V; Campos, AThe molecular pathways behind the toxicity of diarrheic shellfish toxins (DSTs) in bivalves have been scarcely studied. Thus, a shotgun proteomics approach was applied in this work to understand bivalves’ molecular responses to the dinoflagellate Prorocentrum lima (1.0 × 106 cells/L). Protein expression along with toxins levels were analyzed in the gills and digestive gland of the mussel Mytilus galloprovincial...
The antioxidants resveratrol and N-acetylcysteine enhance anthelmintic activity...
Gouveia, M; Brindley, P; Azevedo, C; Gärtner, F; Costa, JMC; Vale, NBackground: Treatment of schistosomiasis has relied on the anthelmintic drug praziquantel (PZQ) for more than a generation. Despite its celebrated performance for treatment and control of schistosomiasis and other platyhelminth infections, praziquantel has some shortcomings and the inability of this drug to counteract disease sequelae prompts the need for novel therapeutic strategies. Methods: Using a host-para...