6 documents found, page 1 of 1
NEK10 interactome and depletion reveal new roles in mitochondria
Kobarg, Jörg
Evidence for the association of the human regulatory protein Ki-1/57 with the t...
Gonçalves, Kaliandra de Almeida; Bressan, Gustavo Costa; Saito, Ângela; Morello, Luis Gustavo; Zanchin, Nilson Ivo T.; Kobarg, JörgKi-1/57 is a cytoplasmic and nuclear protein of 57 kDa first identified in malignant cells from Hodgkin’s lymphoma. Based on yeast-two hybrid protein interaction we found out that Ki-1/57 interacts with adaptor protein RACK1 (receptor of activated kinase 1), CIRP (cold-inducible RNA-binding protein), RPL38 (ribosomal protein L38) and FXR1 (fragile X mental retardation-related protein 1). Since these proteins ar...
Potential antileukemia effect and structural analyses of SRPK inhibition by N-(...
Siqueira, Raoni Pais; Barbosa, Éverton de Almeida Alves; Polêto, Marcelo Depólo; Righetto, Germanna Lima; Seraphim, Thiago VargasDysregulation of pre-mRNA splicing machinery activity has been related to the biogenesis of several diseases. The serine/arginine-rich protein kinase family (SRPKs) plays a critical role in regulating pre-mRNA splicing events through the extensive phosphorylation of splicing factors from the family of serine/arginine-rich proteins (SR proteins). Previous investigations have described the overexpression of SRPK1...
Ki-1/57 and CGI-55 ectopic expression impact cellular pathways involved in prol...
Vidigal, Pedro M.; Costa, Fernanda C.; Saito, Ângela; Gonçalves, Kaliandra A.; Meirelles, Gabriela V.; Bressan, Gustavo C.; Kobarg, JörgKi-1/57 (HABP4) and CGI-55 (SERBP1) are regulatory proteins and paralogs with 40.7% amino acid sequence identity and 67.4% similarity. Functionally, they have been implicated in the regulation of gene expression on both the transcriptional and mRNA metabolism levels. A link with tumorigenesis is suggested, since both paralogs show altered expression levels in tumor cells and the Ki-1/57 gene is found in a regio...
Human regulatory protein Ki-1/57 has characteristics of an intrinsically unstru...
Kobarg, Jörg