4 documents found, page 1 of 1
Global guideline for the diagnosis and management of candidiasis: an initiative...
Cornely, Oliver A.; Sprute, Rosanne; Bassetti, Matteo; Chen, Sharon C-A; Groll, Andreas H.; Kurzai, Oliver; Lass-Flörl, CorneliaCandida species are the predominant cause of fungal infections in patients treated in hospital, contributing substantially to morbidity and mortality. Candidaemia and other forms of invasive candidiasis primarily affect patients who are immunocompromised or critically ill. In contrast, mucocutaneous forms of candidiasis, such as oral thrush and vulvovaginal candidiasis, can occur in otherwise healthy individual...
COVID-19 Associated Pulmonary Aspergillosis (CAPA)—From immunology to treatment
Arastehfar, Amir; Carvalho, Agostinho; van de Veerdonk, Frank L.; Jenks, Jeffrey D.; Koehler, Philipp; Krause, Robert; Cornely, Oliver A.Like severe influenza, coronavirus disease-19 (COVID-19) resulting in acute respiratory distress syndrome (ARDS) has emerged as an important disease that predisposes patients to secondary pulmonary aspergillosis, with 35 cases of COVID-19 associated pulmonary aspergillosis (CAPA) published until June 2020. The release of danger-associated molecular patterns during severe COVID-19 results in both pulmonary epith...
ECMM CandiReg - A ready to use platform for outbreaks and epidemiological studies
Koehler, Philipp; Arendrup, Maiken Cavling; Arikan‐Akdagli, Sevtap; Bassetti, Matteo; Bretagne, Stéphane; Klingspor, Lena; Lagrou, KatrienBackground: Recent outbreaks of Candida auris further exemplify that invasive Candida infections are a substantial threat to patients and healthcare systems. Even short treatment delays are associated with higher mortality rates. Epidemiological shifts towards more resistant Candida spp. require careful surveillance. Objectives: Triggered by the emergence of C auris and by increasing antifungal resistance rates...
Immune parameters for diagnosis and treatment monitoring in invasive mold infec...
Jenks, Jeffrey D.; Rawlings, Stephen A; Garcia-Vidal, Carol; Koehler, Philipp; Mercier, Toine; Prattes, Juergen; Lass-Flörl, CorneliaInfections caused by invasive molds, including Aspergillus spp., can be difficult to diagnose and remain associated with high morbidity and mortality. Thus, early diagnosis and targeted systemic antifungal treatment remains the most important predictive factor for a successful outcome in immunocompromised individuals with invasive mold infections. Diagnosis remains difficult due to low sensitivities of diagnost...