4 documents found, page 1 of 1
Chronic stress triggers divergent dendritic alterations in immature neurons of ...
Dioli, Chrysoula; Patrício, Patrícia; Sousa, Nuno; Kokras, Nikolaos; Dalla, Christina; Guerreiro, Sara; Santos-Silva, Miguel A.; Rego, Ana CristinaChronic stress, a suggested precipitant of brain pathologies, such as depression and Alzheimer's disease, is known to impact on brain plasticity by causing neuronal remodeling as well as neurogenesis suppression in the adult hippocampus. Although many studies show that stressful conditions reduce the number of newborn neurons in the adult dentate gyrus (DG), little is known about whether and how stress impacts ...
Chronic stress triggers divergent dendritic alterations in immature neurons of ...
Dioli, Chrysoula; Patrício, Patrícia; Sousa, Nuno; Kokras, Nikolaos; Dalla, Christina; Guerreiro, Sara; Santos-Silva, Miguel A.; Rego, Ana CristinaChronic stress, a suggested precipitant of brain pathologies, such as depression and Alzheimer's disease, is known to impact on brain plasticity by causing neuronal remodeling as well as neurogenesis suppression in the adult hippocampus. Although many studies show that stressful conditions reduce the number of newborn neurons in the adult dentate gyrus (DG), little is known about whether and how stress impacts ...
Acetyl Cholinesterase Inhibitors and Cell-Derived Peripheral Inflammatory Cytok...
Kokras, Nikolaos; Stamouli, Evangelia; Sotiropoulos, I.; Katirtzoglou, Everina A.; Siarkos, Kostas T.; Dalagiorgou, GeorgiaClinical and preclinical studies firmly support the involvement of the inflammation in the pathogenesis of Alzheimer's disease (AD). Despite acetylcholinesterase inhibitors (AChEI) being widely used in AD patients, there is no conclusive evidence about their impact on the inflammatory response.
Effect of Levodopa on Reward and Impulsivity in a Rat Model of Parkinson's Disease
Carvalho, Miguel M.; Campos, Filipa L.; Marques, Mariana; Cunha, Carina Isabel Soares; Kokras, Nikolaos; Dalla, Christina; Leite-Almeida, HugoThe use of dopamine replacement therapies (DRT) in the treatment of Parkinson's disease (PD) can lead to the development of dopamine dysregulation syndrome (DDS) and impulse control disorders (ICD), behavioral disturbances characterized by compulsive DRT self-medication and development of impulsive behaviors. However, the mechanisms behind these disturbances are poorly understood. In animal models of PD, the as...