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Stress induced risk-aversion is reverted by D2/D3 agonist in the rat

Morgado, Pedro; Marques, Fernanda; Ribeiro, Beatriz; Leite-Almeida, Hugo; Pêgo, José M.; Rodrigues, Ana J.; Dalla, Christina; Kokras, Nikos; Sousa, Nuno

Stress exposure triggers cognitive and behavioral impairments that influence decision-making processes. Decisions under a context of uncertainty require complex reward-prediction processes that are known to be mediated by the mesocorticolimbic dopamine (DA) system in brain areas sensitive to the deleterious effects of chronic stress, in particular the orbitofrontal cortex (OFC). Using a decision-making task, we...


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