4 documents found, page 1 of 1
Carcinoembryonic antigen carrying SLe X as a new biomarker of more aggressive g...
Gomes, C; Almeida, A; Barreira, A; Calheiros, J; Pinto, F; Abrantes, R; Costa, A; Polónia, A; Campos, D; Osorio, H; Sousa, HS; Pinto-De-Sousa, JMalignant transformation of gastric cells is accompanied by the deregulated expression of glycosyltransferases leading to the biosynthesis of tumor-associated glycans such as the sialyl-Lewis X antigen (SLex). SLex presence on cell surface glycoconjugates increases the invasive capacity of gastric cancer cells and is associated with tumor metastasis. ST3Gal IV enzyme is involved in the synthesis of SLex antigen...
Preventing E-cadherin aberrant N-glycosylation at Asn-554 improves its critical...
Carvalho, S; Catarino, TA; Dias, A; Kato, M; Almeida, A; Hessling, B; Figueiredo, J; Gärtner, F; Sanches, J; Ruppert, T; Miyoshi, E; Pierce, ME-cadherin is a central molecule in the process of gastric carcinogenesis and its posttranslational modifications by N-glycosylation have been described to induce a deleterious effect on cell adhesion associated with tumor cell invasion. However, the role that site-specific glycosylation of E-cadherin has in its defective function in gastric cancer cells needs to be determined. Using transgenic mice models and ...
Glycomic and sialoproteomic data of gastric carcinoma cells overexpressing ST3GAL4
Mereiter, S; Magalhães, A; Adamczyk, B; Jin, C; Almeida, A; Drici, L; Ibáñez-Vea, M; Larsen, M; Kolarich, D; Karlsson, N; Reis, CAGastric carcinoma MKN45 cells stably transfected with the full-length ST3GAL4 gene were characterised by glycomic and sialoproteomic analysis. Complementary strategies were applied to assess the glycomic alterations induced by ST3GAL4 overexpression. The N- and O-glycome data were generated in two parallel structural analyzes, based on PGC-ESI-MS/MS. Data on glycan structure identification and relative abundanc...
Glycomic analysis of gastric carcinoma cells discloses glycans as modulators of...
Mereiter, S; Magalhães, A; Adamczyk, B; Jin, C; Almeida, A; Drici, L; Ibáñez-Vea, M; Gomes, C; Ferreira, JA; Afonso, L; Santos, L; Larsen, MBackground Terminal a2-3 and a2-6 sialylation of glycans precludes further chain elongation, leading to the biosynthesis of cancer relevant epitopes such as sialyl-Lewis X (SLe X ). SLe X overexpression is associated with tumor aggressive phenotype and patients' poor prognosis. Methods MKN45 gastric carcinoma cells transfected with the sialyltransferase ST3GAL4 were established as a model overexpressing sialyla...