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TRAP1 Is Expressed in Human Retinal Pigment Epithelial Cells and Is Required to...

Rego, Inês Ramos; Silvério, Daniela; Eufrásio, Maria Isabel; Pinhanços, Sandra Sofia; Lopes da Costa, Bruna; Teixeira, José; Fernandes, Hugo; Kong, Yang

Age-related macular degeneration (AMD) is the leading cause of severe vision loss and blindness in elderly people worldwide. The damage to the retinal pigment epithelium (RPE) triggered by oxidative stress plays a central role in the onset and progression of AMD and results from the excessive accumulation of reactive oxygen species (ROS) produced mainly by mitochondria. Tumor necrosis factor receptor-associated...

Date: 2023   |   Origin: Estudo Geral - Universidade de Coimbra
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