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Health-related quality of life at 5 years of age for children born very preterm...

Kim, SW; Tian, X; Andronis, L; Maier, RF; Varendi, H; Seppänen, A-V; Siljehav, V; Draper, ES; Zeitlin, J; Petrou, S; Seppänen, AV; El Rafei, R

Background: This study aimed to investigate the health-related quality of life (HRQoL) at 5 years of age of European children born very preterm across multi-dimensional outcomes by presence and severity of congenital anomalies. Methods: The study used data from a European cohort of children born very preterm (<32 weeks of gestation) and followed up to 5 years of age (N = 3493). Multilevel Ordinary Least Squares...


Risk factors for cerebral palsy and movement difficulties in 5-year-old childre...

Aubert, AM; Costa, R; Johnson, S; Aden, U; Cuttini, M; Koopman-Esseboom, C; Lebeer, J; Varendi, H; Zemlin, M; Pierrat, V; Zeitlin, J

BackgroundMotor impairment is common after extremely preterm (EPT, <28 weeks' gestational age (GA)) birth, with cerebral palsy (CP) affecting about 10% of children and non-CP movement difficulties (MD) up to 50%. This study investigated the sociodemographic, perinatal and neonatal risk factors for CP and non-CP MD.MethodsData come from a European population-based cohort of children born EPT in 2011-2012 in 11 c...


Motor-related health care for 5-year-old children born extremely preterm with m...

Costa, R; Aubert, AM; Seppänen, A-V; Ådén, U; Sarrechia, L; Zemlin, M; Cuttini, M; Männamaa, M; Pierrat, V; van Heijst, A; Barros, H; Johnson, S

Aim: To (1) determine the proportion of 5-year-old children born extremely preterm (EPT) with movement difficulties including cerebral palsy (CP) and the proportion of these children receiving motor-related health care (MRHC), and (2) describe factors associated with receiving MRHC. Method: Children born before 28 weeks’ gestation in 2011 to 2012 in 11 European countries were assessed with the Movement Assessme...


EPICE cohort: two-year neurodevelopmental outcomes after very preterm birth

Draper, ES; Zeitlin, J; Manktelow, BN; Piedvache, A; Cuttini, M; Edstedt Bonamy, AK; Maier, R; Koopman-Esseboom, C; Gadzinowski, J; Boerch, K

Objective: To determine whether the variation in neurodevelopmental disability rates between populations persists after adjustment for demographic, maternal and infant characteristics for an international very preterm (VPT) birth cohort using a standardised approach to neurodevelopmental assessment at 2 years of age. Design: Prospective standardised cohort study. Setting: 15 regions in 10 European countries. Pa...


Specialist health care services use in a European cohort of infants born very p...

Seppänen, AV; Bodeau-Livinec, F; Boyle, EM; Edstedt-Bonamy, AK; Cuttini, M; Toome, L; Maier, RF; Cloet, E; Koopman-Esseboom, C; Pedersen, P

Aim Children born very preterm require additional specialist care because of the health and developmental risks associated with preterm birth, but information on their health service use is sparse. We sought to describe the use of specialist services by children born very preterm in Europe. Method We analysed data from the multi-regional, population-based Effective Perinatal Intensive Care in Europe (EPICE) coh...


Variability in Very Preterm Stillbirth and In-Hospital Mortality Across Europe

Draper, ES; Manktelow, BN; Cuttini, M; Maier, RF; Fenton, AC; Van Reempts, P; Bonamy, AK; Mazela, J; Bᴓrch, K; Koopman-Esseboom, C; Varendi, H

BACKGROUND AND OBJECTIVE: Stillbirth and in-hospital mortality rates associated with very preterm births (VPT) vary widely across Europe. International comparisons are complicated by a lack of standardized data collection and differences in definitions, registration, and reporting. This study aims to determine what proportion of the variation in stillbirth and in-hospital VPT mortality rates persists after adju...


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