22 documents found, page 1 of 3
The fetal origins of disease: a prospective cohort study on the association of ...
Palma dos Reis, CR; Serrano, F; Fonseca, MJ; Martins, AT; Campos, A; McMahon, GM; Barros, HCardiovascular diseases are the main cause of mortality worldwide, and childhood excess weight/obesity are strong correlators of accumulated risk in later life. A relationship between maternal preeclampsia and offspring’s childhood obesity is recognized, but most studies fail to control for strong confounders. Our goal is to analyze the association between preeclampsia and childhood excess weight/obesity, after...
Adiposity rebound and cardiometabolic health in childhood: results from the Gen...
Fonseca, MJ; Moreira, C; Santos, ACBackground: We aimed to evaluate the association of adiposity rebound (AR) timing on cardiometabolic health in childhood. Methods: Participants were part of the Generation XXI birth cohort, enrolled in 2005/2006 in Porto. All measurements of the child's weight and height performed by health professionals as part of routine healthcare were collected. Individual body mass index (BMI) curves were fitted for 3372 c...
Association of Pubertal Development With Adiposity and Cardiometabolic Health i...
Fonseca, MJ; Oliveira, A; Azevedo, I; Nunes, J; Santos, ACPurpose Early timing of pubertal development is associated with worse cardiometabolic health in adulthood. We aimed to evaluate this association in 10-year-old girls and boys and clarify if it is independent of previous body mass index (BMI). Methods Pubertal development was evaluated through the Tanner scale in 4,548 children from the birth cohort Generation XXI. Data on anthropometrics, body composition, bloo...
Direct and BMI-mediated effect of birthweight on childhood cardio-metabolic hea...
Fonseca, MJ; Severo, M; Lawlor, DA; Barros, H; Santos, ACBackground Different directions of the association of birthweight with cardio-metabolic health have been found, especially in children, which may be explained by the mediating effect of attained adiposity. We aimed to untangle direct and BMI-mediated associations of birthweight with childhood cardio-metabolic indicators. Methods Children from Generation XXI birth cohort were included (n = 4881). Birthweight was...
Early childhood as a sensitive period for the effect of growth on childhood bon...
Monjardino, T; Amaro, J; Fonseca, MJ; Rodrigues, T; Santos, AC; Lucas, RBackground To identify sensitive periods for the effect of early life growth on childhood bone mass we compared the associations between weight and length/height velocities from birth to age six and bone mineral content (BMC) and areal density (aBMD) at 7 years of age. Methods We analyzed data from 1853 participants from the Generation XXI birth cohort scanned with a whole body dual-energy X-ray absorptiometry ...
Different levels of cardiometabolic indicators in multiple vs. singleton children
Fonseca, MJ; Santos, AC; Barros, HBackground We aimed to compare cardiometabolic indicators in singletons and multiples at age 7 and explore the birthweight mediation effect. Methods We studied 5431 singletons and 103 sets of multiples from Generation XXI birth cohort. Anthropometric measurements, body composition, and fasting blood samples were obtained. Age- and sex-specific z-scores were calculated (additionally height-specific for blood pre...
A Multistate Model for Analyzing Transitions Between Body Mass Index Categories...
Moreira, C; Meira-Machado, L; Fonseca, MJ; Santos, ACPrevalences of overweight and obesity in young children have risen dramatically in the last several decades in most developed countries. Childhood overweight and obesity are known to have immediate and long-term health consequences and are now recognized as important public health concerns. We used a Markov 4-state model with states defined by 4 body mass index (BMI; weight (kg)/height (m)(2)) categories (under...
Maternal smoking: a life course blood pressure determinant?
Cabral, M; Fonseca, MJ; González-Beiras, C; Santos, AC; Correia-Costa, L; Barros, HIntroduction: Exposure to maternal smoking early in life may affect blood pressure (BP) control mechanisms. We examined the association between maternal smoking (before conception, during pregnancy, and 4 years after delivery) and BP in preschool children. Methods: We evaluated 4295 of Generation XXI children, recruited at birth in 2005–2006 and reevaluated at the age of 4. At birth, information was collected b...
Effect of maternal country of birth on breastfeeding practices: results from Po...
Kana, MA; Rodrigues, C; Fonseca, MJ; Santos, AC; Barros, HBackground: Maternal country of birth has been associated with perinatal health outcomes but less is known regarding breastfeeding practices in contemporary European settings. This study investigated effect of maternal country of birth on breastfeeding initiation and duration by comparing native Portuguese and migrant mothers. Methods: We analyzed data of 7065 children of the Generation XXI (GXXI) birth cohort ...
Newborn weight change and childhood cardio-metabolic traits - a prospective coh...
Fonseca, MJ; Severo, M; Lawlor, DA; Barros, H; Santos, ACBackground: Newborn weight change (NWC) in the first 4 days represents short-term adaptations to external environment. It may be a key developmental period for future cardio-metabolic health, but this has not been explored. We aimed to determine the associations of NWC with childhood cardio-metabolic traits. Methods: As part of Generation XXI birth cohort, children were recruited in 2005/2006 at all public unit...