11 documents found, page 1 of 2
Risk factors for postoperative endoscopic recurrence in Crohn's disease: a Braz...
Barcelos,Ivan Folchini de; Silva,Rodolff Nunes da; Teixeira,Fábio Vieira; Albuquerque,Idblan Carvalho de; Saad-Hossne,Rogério; Ropelato,Renato VismaraIntroduction: Postoperative endoscopic recurrence (PER) is the initial event after intestinal resection in Crohn's disease (CD), and after a few years most patients present with progressive symptoms and complications related to the disease. The identification of risk factors for PER can help in the optimization of postoperative therapy and contribute to its prevention. Methods: Retrospective, longitudinal, mult...
Comparative analysis of adverse events between infliximab and adalimumab in Cro...
Kotze,Paulo Gustavo; Akiyoshi,Fernando Kenji; Luvizotto,Mateus; Olandoski,Márcia; Kotze,Lorete Maria da Silva; Coy,Cláudio Saddy RodriguesINTRODUCTION: Data is scarce regarding adverse events (AE) of biological therapy used in the management of Crohn's Disease (CD) among Brazilian patients. OBJECTIVES: To analyse AE prevalence and profile in patients with CD treated with Infliximab (IFX) or Adalimumab (ADA) and to verify whether there are differences between the two drugs. METHOD: Retrospective observational single-centre study of CD patients on ...
Complications after intestinal resection in Crohn's disease: laparoscopic versu...
Kotze,Paulo Gustavo; Abou-Rejaile,Vinícius Rezende; Barcelos,Ivan Folchini de; Martins,Juliana Ferreira; Miranda,Eron Fábio; Rocha,Juliana GonçalvesBACKGROUND: significant advances in medical therapy for Crohn's disease (CD) occurred in the last 12 years, mainly due to the introduction of anti-TNF therapy. Laparoscopic colorectal surgery represented the most important advance on surgical treatment in the management of CD, as it also had developed in the treatment of other conditions. There is a tendency for lower complication rates after laparoscopic bowel...
Epidemiological profile of 175 patients with Crohn's disease submitted to biolo...
Hardt,Marcelo Rassweiler; Kotze,Paulo Gustavo; Teixeira,Fabio Vieira; Ludvig,Juliano Coelho; Malluta,Everson Fernando; Kleinubing Junior,HarryINTRODUCTION: There is currently an increasing use of biological agents in the management of Crohn's disease (CD). There is lack of data regarding the epidemiological profile of patients on infliximab (IFX) and adalimumab (ADA) for CD in Brazil. OBJECTIVE: To identify the epidemiological characteristics of patients with CD who underwent biological therapy. METHOD: Retrospective multicenter study, with CD patien...
Adalimumab in the induction of Crohn's disease remission: results of a Brazilia...
Kotze,Paulo Gustavo; Vieira,Andrea; Sobrado Junior,Carlos Walter; Salem,Juliana Barreto; Kotze,Lorete Maria da SilvaIntroduction: Adalimumab (ADA) is a subcutaneous fully-human anti-TNF antibody which has a significant role in the management of Crohn's disease (CD). Its efficacy has been demonstrated in several clinical trials. The main objective of this study was to evaluate the role of ADA in the induction of clinical remission in a Brazilian series of CD cases. Method: A retrospective analysis of CD patients treated with ...
Reindução da remissão clínica com adalimumabe após interrupção do tratamento: u...
Kotze,Paulo Gustavo; Albuquerque,Idblan Carvalho de; Kotze,Lorete Maria da Silva; Formiga,Galdino José SitonioIntrodução: o Adalimumabe (ADA) é um anticorpo monoclonal totalmente humano, utilizado no tratamento da doença de Crohn (DC). Nos casos com necessidade de interrupção desta terapia, o resgate da resposta é controverso, e o papel da reindução da remissão com dose total de ataque pode ser uma alternativa nos casos graves da DC. Não há relatos desta forma de tratamento na literatura. O objetivo deste estudo foi re...
Antibodies anti-Saccharomyces cerevisiae (ASCA) do not differentiate Crohn's di...
Kotze,Lorete Maria da Silva; Nisihara,Renato Mitsunori; Utiyama,Shirley Ramos da Rosa; Kotze,Paulo Gustavo; Theiss,Petra Mirella; Olandoski,MárciaCONTEXT: Anti-Saccharomyces cerevisiae antibodies (ASCA), considered serologic markers for Crohn's disease, were described in patients with celiac disease, disappearing after a gluten-free diet. OBJECTIVES: Evaluation of ASCA positivity in patients with Crohn's disease and celiac disease in relation to healthy individuals. METHODS: A total of 145 individuals were studied: 36 with Crohn's disease and 52 with cel...
Celiac disease in Brazilian patients: associations, complications and causes of...
Kotze,Lorete Maria da SilvaCONTEXT: Celiac disease is a multisystem auto-immune disorder and may start at any age in genetically predisposed individuals. OBJECTIVE: To identify associations, complications, and cause of death in Brazilian patients. METHODS: One hundred and fifty-seven patients were studied: 23 adolescents and 134 adults, 79.6% females, 20.4% males, 75.8% at the time of diagnosis and 24.2% on a gluten-free diet, follow-up ...
Triagem sorológica de familiares de pacientes com doença celíaca: anticorpos an...
Utiyama,Shirley Ramos da Rosa; Nass,Flávia Raphaela; Kotze,Lorete Maria da Silva; Nisihara,Renato Mitsunori; Ambrosio,Altair RogérioRACIONAL: A doença celíaca representa, na atualidade, a doença intestinal mais comum em populações caucasóides e apresenta prevalência que varia de 8% a 18% nos familiares dos pacientes. A pesquisa dos anticorpos anti-endomísio (EmA-IgA) e antitransglutaminase tecidual (anti-tTG-IgA) constitui importante recurso não-invasivo e sensível de triagem e diagnóstico da doença celíaca em grupos de risco e populações. ...
Aspectos genéticos e imunopatogênicos da doença celíaca: visão atual
Utiyama,Shirley Ramos da Rosa; Reason,Iara José Taborda de Messias; Kotze,Lorete Maria da SilvaRACIONAL: A doença celíaca ou enteropatia por sensibilidade ao glúten, é uma forte condição hereditária. Embora a associação genética da doença celíaca com os haplótipos HLA-DQ2 e DQ8 seja conhecida há muito tempo, outros genes HLA e não-HLA também são importantes no desenvolvimento da afecção. A doença celíaca resulta de um efeito combinado de produtos de diferentes genes funcionantes normalmente. A lesão inte...