28 documents found, page 1 of 3
Sucralfate enemas reduce the oxidative tissue damage and preserves the contents...
Sato,Daniela Tiemi; Campos,Fabio Guilherme; Kotze,Paulo Gustavo; Mendonça,Roberta Laís Santos; Kanno,Danilo Toshio; Pereira,José AiresABSTRACT Purpose: To evaluate the effects of sucralfate enemas in tissue contents of E-cadherin and ?-catenin in an experimental diversion colitis. Methods: Thirty-six male Wistar rats were submitted to a proximal colostomy and a distal mucous fistula. They were allocated into three groups: first group received daily saline enemas (2 mL/day) and the two other groups daily enemas with sucralfate at dosage of 1 o...
Perioperative Nutritional Optimization in Inflammatory Bowel Diseases: When and...
Silva,Isadora Sayuri Macedo da; Cambi,Maria Paula Carlini; Magro,Daniéla Oliveira; Kotze,Paulo GustavoAbstract Inflammatory bowel diseases (IBDs), including ulcerative colitis (UC) and Crohn’s disease (CD), are commonly associated with important changes in nutritional status (NS). Both malnutrition and obesity have a negative impact on the course of both diseases, with greater risks of postoperative complications, such as anastomotic dehiscences, reoperations, prolonged hospitalizations, and increased mortality...
Effects of anti-TNF-α in experimental diversion colitis
Buanaim,Ronaldo Parisi; Pereira,José Aires; Campos,Fabio Guilherme; Kotze,Paulo Gustavo; Goto,Eduardo Felipe Kim; Mendonça,Roberta Laís SilvaAbstract Purpose: To evaluate the effects of infliximab on the inflammation of the colonic mucosa devoid from fecal stream. Methods: Twenty-four rats were submitted to a Hartmann's procedure. They remained for 12 weeks with the fecal derivation to development of diversion colitis on excluded colorectal stump. After this period, they were divided into 3 groups: one group received intervention with saline (2.0 mL...
Postoperative mortality in inflammatory bowel disease patients
Ropelato,Renato Vismara; Kotze,Paulo Gustavo; Froehner Junior,Ilário; Dadan,Danieli D.; Miranda,Eron FábioABSTRACT Introduction: Since the 1960s, mortality in Crohn's disease and Ulcerative Colitis patients had a significant decrease due to advances in medical and surgical therapy. An important proportion of these patients are submitted to surgical procedures during their disease course, with postoperative mortality between 4 and 10%. Methods: 157 inflammatory bowel disease patients submitted to surgical therapy we...
Postoperative complication rates between Crohn's disease and Colorectal cancer ...
Boaron,Larissa; Facchin,Luiza; Bau,Mariella; Zacharias,Patricia; Ribeiro,Diogo; Miranda,Eron Fábio; Barcelos,Ivan Folchini de; Ropelato,Renato VismaraABSTRACT Introduction: Ileocolic resection (ICR) is the most common surgical procedure performed for Crohn's disease (CD). Similarly, right-sided Colorectal cancer (CRC) is treated by the same operation. The primary aim of this study was to analyze and compare the frequency and profile of early postoperative complications of ICR between patients with CD and CRC. Methods: Retrospective and observational study wi...
Double single-port transanal pouch surgery: a novel technique for rectal excisi...
Warusavitarne,Janindra; Kotze,Paulo GustavoABSTRACT Surgery for ileoanal pouch has evolved dramatically over the last 30 years. Many of the advances relate to minimally invasive approaches that not only offer cosmetic benefits but also have advantages that are well described in the literature. In this technical note, the authors describe the double single-port transanal pouch operation. An abdominal single-port is used for total colectomy, at the site o...
Impact of anti-TNF agents in postoperative complications in Crohn's disease: a ...
Saab,Mansur; Saab,Bárbara; Olandoski,Márcia; Coy,Cláudio Saddy Rodrigues; Kotze,Paulo GustavoThe real impact of biological therapy (anti-TNF agents) in abdominal operations secondary to Crohn's disease is a matter of debate in the international literature. Several studies demonstrated that there can be an increase in postoperative complications in patients previously treated with these agents. On the other hand, the majority of studies published over the last years question this effect, and did not dem...
Risk factors for postoperative endoscopic recurrence in Crohn's disease: a Braz...
Barcelos,Ivan Folchini de; Silva,Rodolff Nunes da; Teixeira,Fábio Vieira; Albuquerque,Idblan Carvalho de; Saad-Hossne,Rogério; Ropelato,Renato VismaraIntroduction: Postoperative endoscopic recurrence (PER) is the initial event after intestinal resection in Crohn's disease (CD), and after a few years most patients present with progressive symptoms and complications related to the disease. The identification of risk factors for PER can help in the optimization of postoperative therapy and contribute to its prevention. Methods: Retrospective, longitudinal, mult...
Postoperative topical analgesia of hemorrhoidectomy with policresulen and cinch...
Froehner Junior,Ilario; Kotze,Paulo Gustavo; Rocha,Juliana Gonçalves; Miranda,Eron Fábio; Sartor,Maria Cristina; Martins,Juliana FerreiraOBJECTIVE: To evaluate the effects of topical policresulen and cinchocaine in the postoperative pain behavior of open hemorrhoidectomy.METHODS: We conducted a prospective, double-blinded, controlled study. The control group received the usual guidelines with oral medications. The topical treatment group received, in addition, the application of the ointment and was comprised of two subgroups (policresulen + cin...
Comparative analysis of adverse events between infliximab and adalimumab in Cro...
Kotze,Paulo Gustavo; Akiyoshi,Fernando Kenji; Luvizotto,Mateus; Olandoski,Márcia; Kotze,Lorete Maria da Silva; Coy,Cláudio Saddy RodriguesINTRODUCTION: Data is scarce regarding adverse events (AE) of biological therapy used in the management of Crohn's Disease (CD) among Brazilian patients. OBJECTIVES: To analyse AE prevalence and profile in patients with CD treated with Infliximab (IFX) or Adalimumab (ADA) and to verify whether there are differences between the two drugs. METHOD: Retrospective observational single-centre study of CD patients on ...