2 documents found, page 1 of 1
Epigenetic alterations in Fanconi Anaemia: Role in pathophysiology and therapeu...
Belo, Hélio José Loureno Miguens Rodrigues; Silva, Gabriela; Cardoso, Bruno; Porto, Beatriz; Minguillon, Jordi; Casado, JorgeFanconi anaemia (FA) is an inherited disorder characterized by chromosomal instability. The phenotype is variable, which raises the possibility that it may be affected by other factors, such as epigenetic modifications. These play an important role in oncogenesis and may be pharmacologically manipulated. Our aim was to explore whether the epigenetic profiles in FA differ from non-FA individuals and whether thes...
Increased levels of chromosomal aberrations and DNA damage in a group of worker...
Costa, Solange; Carvalho, Sandra; Costa, Carla; Coelho, Patrícia; Silva, Susana; Santos, Luís S.; Gaspar, Jorge F.; Porto, Beatriz; Laffon, BlancaFunding: Fundação para a Ciência e a Tecnologia (FCT) (SFRH/BD/46929/ 2008 and PTDC/SAUESA/102367/2008).; Formaldehyde (FA) is a commonly used chemical in anatomy and pathology laboratories as a tissue preservative and fixative. Because of its sensitising properties, irritating effects and cancer implication, FA accounts probably for the most important chemical-exposure hazard concerning this professional group...