Funding Information: This work was supported by EU Horizon 2020 Research & Innovation programme (H2020-NMBP-BIO-2017) (grant number 760891), European Commission program Teaming for Excellence, Grant No. 101060346, the European Union\u2019s Horizon 2020 research and innovation programme under grant agreement No. 951921, NORTE2030-FEDER-01777300 - SCALE-ImmunoHUB2030 supported by Norte Portugal Regional Operation...
Publisher Copyright: © 2020, The Author(s).; An amendment to this paper has been published and can be accessed via a link at the top of the paper.
As a first host barrier, the skin is constantly exposed to environmental insults that perturb its integrity. Tight regulation of skin homeostasis is largely controlled by the aryl hydrocarbon receptor (AhR). Here, we demonstrate that Henna and its major pigment, the naphthoquinone Lawsone activate AhR, both in vitro and in vivo. In human keratinocytes and epidermis equivalents, Lawsone exposure enhances the pro...