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Mycobacterium leprae diversity and population dynamics in medieval Europe from ...

Pfrengle, Saskia; Neukamm, Judith; Guellil, Meriam; Keller, Marcel; Molak, Martyna; Avanzi, Charlotte; Kushniarevich, Alena; Montes, Núria

BACKGROUND: Hansen's disease (leprosy), widespread in medieval Europe, is today mainly prevalent in tropical and subtropical regions with around 200,000 new cases reported annually. Despite its long history and appearance in historical records, its origins and past dissemination patterns are still widely unknown. Applying ancient DNA approaches to its major causative agent, Mycobacterium leprae, can significant...


Palaeogenomic analysis of black rat (Rattus rattus) reveals multiple european i...

Yu, He; Jamieson, Alexandra; Hulme-Beaman, Ardern; Conroy, Chris J.; Knight, Becky; Speller, Camilla; Al-Jarah, Hiba; Eager, Heidi; Trinks, Alexandra

The distribution of the black rat (Rattus rattus) has been heavily influenced by its association with humans. The dispersal history of this non-native commensal rodent across Europe, however, remains poorly understood, and different introductions may have occurred during the Roman and medieval periods. Here, in order to reconstruct the population history of European black rats, we first generate a de novo genom...


Mycobacterium leprae diversity and population dynamics in medieval Europe from ...

Pfrengle, Saskia; Neukamm, Judith; Guellil, Meriam; Keller, Marcel; Molak, Martyna; Avanzi, Charlotte; Kushniarevich, Alena; Montes, Núria

Hansen's disease (leprosy), widespread in medieval Europe, is today mainly prevalent in tropical and subtropical regions with around 200,000 new cases reported annually. Despite its long history and appearance in historical records, its origins and past dissemination patterns are still widely unknown. Applying ancient DNA approaches to its major causative agent, Mycobacterium leprae, can significantly improve o...


Mycobacterium leprae diversity and population dynamics in medieval Europe from ...

Pfrengle, Saskia; Neukamm, Judith; Guellil, Meriam; Keller, Marcel; Molak, Martyna; Avanzi, Charlotte; Kushniarevich, Alena; Montes, Núria

Background: Hansen’s disease (leprosy), widespread in medieval Europe, is today mainly prevalent in tropical and subtropical regions with around 200,000 new cases reported annually. Despite its long history and appearance in historical records, its origins and past dissemination patterns are still widely unknown. Applying ancient DNA approaches to its major causative agent, Mycobacterium leprae, can significant...


Mycobacterium leprae diversity and population dynamics in medieval Europe from ...

Pfrengle, Saskia; Neukamm, Judith; Guellil, Meriam; Keller, Marcel; Molak, Martyna; Avanzi, Charlotte; Kushniarevich, Alena; Montes, Núria

Background: Hansen’s disease (leprosy), widespread in medieval Europe, is today mainly prevalent in tropical and subtropical regions with around 200,000 new cases reported annually. Despite its long history and appearance in historical records, its origins and past dissemination patterns are still widely unknown. Applying ancient DNA approaches to its major causative agent, Mycobacterium leprae, can significant...


The Beaker phenomenon and the genomic transformation of northwest Europe

Olalde, Iñigo; Brace, Selina; Allentoft, Morten E; Armit, Ian; Kristiansen, Kristian; Booth, Thomas; Rohland, Nadin; Mallick, Swapan

From around 2750 to 2500 bc, Bell Beaker pottery became widespread across western and central Europe, before it disappeared between 2200 and 1800 bc. The forces that propelled its expansion are a matter of long-standing debate, and there is support for both cultural diffusion and migration having a role in this process. Here we present genome-wide data from 400 Neolithic, Copper Age and Bronze Age Europeans, in...


The beaker phenomenon and the genomic transformation of Northwest Europe

Olalde, Iñigo; Brace, Selina; Allentoft, Morten E.; Armit, Ian; Kristiansen, Kristian; Rohland, Nadin; Mallick, Swapan; Booth, Thomas

From around 2750 to 2500 BC, Bell Beaker pottery became widespread across western and central Europe, before it disappeared between 2200 and 1800 BC. The forces that propelled its expansion are a matter of long-standing debate, and there is support for both cultural diffusion and migration having a role in this process. Here we present genome-wide data from 400 Neolithic, Copper Age and Bronze Age Europeans, in...


The maternal genetic make-up of the Iberian Peninsula between the Neolithic and...

Szécsényi-Nagy, Anna; Roth, Christina; Brandt, Guido; Rihuete-Herrada, Cristina; Tejedor-Rodríguez, Cristina; Held, Petra

Agriculture first reached the Iberian Peninsula around 5700 BCE. However, little is known about the genetic structure and changes of prehistoric populations in different geographic areas of Iberia. In our study, we focus on the maternal genetic makeup of the Neolithic (~ 5500-3000 BCE), Chalcolithic (~ 3000-2200 BCE) and Early Bronze Age (~ 2200-1500 BCE). We report ancient mitochondrial DNA results of 213 indi...


The maternal genetic make-up of the Iberian Peninsula between the Neolithic and...

Szécsényi-Nagy, Anna; Roth, Christina; Brandt, Guido; Rihuete-Herrada, Cristina; Tejedor-Rodríguez, Cristina; Held, Petra

Agriculture first reached the Iberian Peninsula around 5700 BCE. However, little is known about the genetic structure and changes of prehistoric populations in different geographic areas of Iberia. In our study, we focus on the maternal genetic makeup of the Neolithic (~ 5500-3000 BCE), Chalcolithic (~ 3000-2200 BCE) and Early Bronze Age (~ 2200-1500 BCE). We report ancient mitochondrial DNA results of 213 indi...


The beaker phenomenon and the Genomic transformations of Northwest Europe

Olalde, Iñigo; Brace, Selina; Allentoft, Morten E.; Armit, Ian; Kristiansen, Kristian; Rohland, Nadin; Mallick, Swapan; Booth, Thomas

Bell Beaker pottery spread across western and central Europe beginning around 2750 BCE before disappearing between 2200-1800 BCE. The mechanism of its expansion is a topic of long-standing debate, with support for both cultural diffusion and human migration. We present new genome-wide ancient DNA data from 170 Neolithic, Copper Age and Bronze Age Europeans, including 100 Beaker-associated individuals. In contra...


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