4 documents found, page 1 of 1
MicroRNA-143 reduces viability and increases sensitivity to 5-fluorouracil in H...
Borralho, Pedro M.; Kren, Betsy T.; Castro, Rui E.; da Silva, Isabel B. Moreira; Steer, Clifford J.; Rodrigues, Cecilia M. P.MicroRNAs are aberrantly expressed in cancer; microRNA-143 (miR-143) is down-regulated in colon cancer. HCT116 human colorectal cancer cells were used to investigate the biological role of miR-143. Transient miR-143 overexpression resulted in an approximate 60% reduction in cell viability. In addition, stable miR-143 overexpressing cells were selected with G418 and exposed to 5-fluorouracil. Increased stable ex...
Administration of thuroursodeoxycholic acid (TUDCA) reduces apoptosis following...
Rivard, Andrew L.; Steer, Clifford J.; Kren, Betsy T.; Rodrigues, Cecilia M. P.; Castro, Rui E.; Bianco, Richard W.; Low, Walter C.Black bear bile has been used in traditional Chinese medicine to treat liver and eye related illnesses for centuries. A major constituent of bile is ursodeoxycholic acid (UDCA). Recent analysis of the cellular effects of UDCA and its taurine conjugate tau
Differential regulation of cyclin D1 and cell death by bile acids in primary ra...
Castro, Rui E.; Amaral, Joana D.; Sola, Susana; Kren, Betsy T.; Steer, Clifford J.; Rodrigues, Cecilia M. P.Ursodeoxycholic ( UDCA) and tauroursodeoxycholic ( TUDCA) acids modulate apoptosis and regulate cell- cycle effectors, including cyclin D1. In contrast, deoxycholic acid ( DCA) induces cell death and cyclin D1. In this study, we explored the role of cycli
Tauroursodeoxycholic acid reduces apoptosis following myocardial infarction in ...
Rivard, Andrew L.; Steer, Clifford J.; Kren, Betsy T.; Rodrigues, Cecilia M.; Castro, Rui E.; Bianco, Richard W.; Low, Walter C.