9 documents found, page 1 of 1
Barriers faced by patients in the diagnosis of multidrug-resistant tuberculosis...
Bhering,Marcela; Dalcolmo,Margareth; Sarubbi Júnior,Vicente; Kritski,AfrânioABSTRACT OBJECTIVE To understand patients’ narratives about the barriers they faced in the diagnosis and treatment of multidrug-resistant tuberculosis, and their consequences in Rio de Janeiro State, Brazil. METHODS This is a qualitative cross-sectional study with non-probabilistic sampling. A theoretical saturation criterion was considered for composing the number of interviewees. Semi-structured interviews we...
Cost-effectiveness of Xpert®MTB/RIF in the diagnosis of tuberculosis: pragmatic...
Silva,Suely Conceição Alves da; Vater,Maria Claudia; Ramalho,Daniela Maria de Paula; Almeida,Isabela Neves de; Miranda,Silvana Spíndola deAbstract INTRODUCTION: The intensification of research and innovation with the creation of networks of rapid and effective molecular tests as strategies for the end of tuberculosis are essential to avoid late diagnosis and for the eradication of the disease. We aimed to evaluate the cost-effectiveness of Xpert®MTB/RIF (Xpert) in the diagnosis of drug-resistant tuberculosis in reference units, in scenarios with ...
Multidrug-resistant tuberculosis in Portugal: patients’ perception of the chall...
Bhering,Marcela; Sarubbi Junior,Vicente; Kritski,Afrânio; Souza,Fabiana Barbosa Assumpção; Duarte,RaquelAbstract Introduction: The increase in drug-resistant tuberculosis (TB) threatens global progress in eliminating TB, and constitutes a major challenge for patients, health-care workers and health services. Treatment for multidrug-resistant TB (MDR TB) can last almost 2 years, and is more expensive, more toxic, and less effective than treating TB caused by drug-sensitive bacilli. This study aims to analyze patie...
Clinical impact and cost analysis of the use of either the Xpert MTB Rif test o...
Castro,Anália Zuleika de; Moreira,Adriana Rezende; Oliveira,Jaqueline; Costa,Paulo Albuquerque; Graça,Carolyne Lalucha Alves Lima DaAbstract INTRODUCTION: The molecular test Xpert MTB/RIF (Xpert) has been recommended for use in the diagnosis of pulmonary tuberculosis (PTB); however, data on the cost of incorporating it under routine conditions in high-burden countries are scarce. The clinical impact and costs incurred in adopting the Xpert test in routine PTB diagnosis was evaluated in a prospective study conducted from November 2012 to Nov...
Completeness of tuberculosis reporting forms for disease control in individuals...
Lírio,Monique; Santos,Normeide Pedreira dos; Passos,Louran Andrade Reis; Kritski,Afrânio; Galvão-Castro,Bernardo; Grassi,Maria Fernanda RiosThe control of HIV / Tuberculosis (TB) co -infection remains a challenge for public health. Notification is mandatory for both diseases and the National Case Registry Database (Sinan) is responsible for the collection and processing of individual forms of reporting and monitoring. The adequate fulfillment of these fields chips (completeness) is essential to follow the dynamics of the disease and set priorities ...
Assessing new strategies for TB diagnosis in low- and middle-income countries
Kritski,Afrânio; Fujiwara,Paula I.; Vieira,Maria Armanda; Netto,Antonio Ruffino; Oliveira,Martha Maria; Huf,Gisele; Squire,S. BertelIn this manuscript, we report the current situation of tuberculosis globally and in Brazil, the need for new strategies toward tuberculosis control, focusing on new diagnostic technologies. Critical comments are given on the state of the art regarding the evaluation of new health technologies, degree of scientific evidence needed, evaluation of clinical impact, cost-effectiveness of incorporation into the healt...
Avaliação da utilidade clínica de novos testes diagnósticos em tuberculose: o p...
Huf,Gisele; Kritski,AfrânioA tuberculose é uma das principais doenças infecciosas em países em desenvolvimento, e o tempo durante o qual a cadeia de transmissibilidade é mantida tem sido apontado como um dos principais fatores de perpetuação da doença. Nesse contexto, novas ferramentas para o diagnóstico têm sido aprovadas pelas agências regulamentadoras nesses países, e sua incorporação é quase imediatamente implementada pelos programas...
Fatores associados ao atraso no diagnóstico da tuberculose pulmonar no estado d...
Machado,Audry Cristina de Fátima Teixeira; Steffen,Ricardo Ewbank; Oxlade,Olivia; Menzies,Dick; Kritski,Afrânio; Trajman,AneteOBJETIVO: Estimar o tempo decorrido entre início dos sintomas e diagnóstico de tuberculose pulmonar (tempo do paciente, desde o início dos sintomas até a primeira visita médica, e tempo do sistema de saúde, desde a primeira visita até o diagnóstico) e analisar os fatores associados ao atraso no diagnóstico da tuberculose pulmonar no estado do Rio de Janeiro. MÉTODOS: Inquérito baseado em questionário com 218 pa...
Internal control in PCR for Mycobacterium tuberculosis: usefulness and improvem...
Cortez-Herrera,Elizabeth; Sperhacke,Rosa Dea; Becker,Daniela; Kritski,Afrânio; Zaha,Arnaldo; Rossetti,Maria Lucia RosaThe aim of this work was to construct and test a plasmidial Internal Control (IC) to detect the inhibition in the PCR test for M. tuberculosis and also its contribution for a Public Health Laboratory routine. The IC was a 600-bp of DNA linked to a plasmid with the same primer sites, allowing the amplification with the 245-bp diagnostic fragment. The amplification of the positive samples rendered the IC and the ...