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Fatores associados à subnotificação de casos de tuberculose multirresistente no...
Silva,Marcela Lopes Bhering da; Durovini,Patrícia; Mota,Paulo; Kritski,Afrânio LineuNeste estudo, estimou-se a proporção e os fatores associados à subnotificação da tuberculose multirresistente (TB-MDR) no Estado do Rio de Janeiro, Brasil, assim como a proporção de óbitos nesse grupo. Realizou-se um estudo de coorte retrospectiva, utilizando a técnica de relacionamento probabilístico entre sistemas de informação. Os casos com resultado do teste de sensibilidade às drogas (TSA) com padrão TB-MD...
Genotype®MTBDRplus and Xpert®MTB/RIF in the diagnosis of tuberculosis and resis...
Soares,Valéria Martins; Almeida,Isabela Neves de; Vater,Maria Cláudia; Alves,Suely; Figueredo,Lida Jouca de Assis; Scherer,LucieneAbstract INTRODUCTION: The present study sought to assess the mean and activity based cost (ABC) of the laboratory diagnosis for tuberculosis through the application of conventional and molecular techniques-Xpert®MTB/RIF and Genotype®MTBDRplus-in a tertiary referral hospital in Brazil. METHODS: The mean cost and ABC formed the basis for the cost analysis of the TB laboratory diagnosis. RESULTS: The mean cost an...
The clinical and molecular diagnosis of childhood and adolescent pulmonary tube...
Aurilio,Rafaela Baroni; Luiz,Ronir Raggio; Land,Marcelo Gerardin Poirot; Cardoso,Claudete Aparecida Araújo; Kritski,Afrânio LineuAbstract INTRODUCTION: The diagnostic accuracy of Xpert MTB/RIF (Xpert) in pulmonary tuberculosis (PTB) in children is lower than in adults. In Brazil, the diagnosis of PTB is based on a diagnostic score system (DSS). This study aims to study the role of Xpert in children and adolescents with PTB symptoms. METHODS: A cross-sectional study was conducted in 3 referral centers to TB. Children and adolescents (0-19...
Cost analysis of smear microscopy and the Xpert assay for tuberculosis diagnosi...
Figueredo,Lida Jouca de Assis; Miranda,Silvana Spíndola de; Santos,Lucas Benício dos; Manso,Caroline Gontijo Gonçalves; Soares,Valéria MartinsAbstract INTRODUCTION: Rapid and accurate tuberculosis detection is critical for improving patient diagnosis and decreasing tuberculosis transmission. Molecular assays can significantly increase laboratory costs; therefore, the average time and economic impact should be evaluated before implementing a new technology. The aim of this study was to evaluate the cost and average turnaround time of smear microscopy ...
Detection of Drug Resistant Mycobacterium Tuberculosis Strains Using Kit SIRE N...
Miranda,Silvana Spindola de; Almeida,Isabela Neves de; Mansur,Maria de Fátima Filardi Oliveira; Figueredo,Lida Jouca de Assis; Carvalho,Wânia da SilvaAbstract (1) Background: The Commercial Kit SIRE Nitratase® PlastLabor, is a drug susceptibility test kit used to detect Mycobacterium tuberculosis resistance to first-line TB treatment drugs. The present study aimed at evaluating its performance in a multicenter study. (2) Methods: To determine its accuracy, the proportion methods in Lowenstein Jensen medium or the BACTECTMMGITTM960 system was used as a gold s...
Social determinants of health and catastrophic costs associated with the diagno...
Moreira,Adriana da Silva Rezende; Kritski,Afrânio Lineu; Carvalho,Anna Cristina CalçadaABSTRACT The epidemiological relevance of tuberculosis is directly related to the socioeconomic profile of a given country. Vulnerability to tuberculosis is influenced by biological factors (e.g., malnutrition, HIV infection, and age) and social factors (e.g., unhealthy housing, high population density, inappropriate working conditions, and lack of access to health services). In many cases, multiple vulnerabili...
Sequential analysis as a tool for detection of amikacin ototoxicity in the trea...
Vasconcelos,Karla Anacleto de; Frota,Silvana Maria Monte Coelho; Ruffino-Netto,Antonio; Kritski,Afrânio LineuABSTRACT Objective: To investigate early detection of amikacin-induced ototoxicity in a population treated for multidrug-resistant tuberculosis (MDR-TB), by means of three different tests: pure-tone audiometry (PTA); high-frequency audiometry (HFA); and distortion-product otoacoustic emission (DPOAE) testing. Methods: This was a longitudinal prospective cohort study involving patients aged 18-69 years with a di...
Predictors of mortality among intensive care unit patients coinfected with tube...
Ferreira,Marcia Danielle; Neves,Cynthia Pessoa das; Souza,Alexandra Brito de; Beraldi-Magalhães,Francisco; Migliori,Giovanni BattistaABSTRACT Objective: To identify factors predictive of mortality in patients admitted to the ICU with tuberculosis (TB)/HIV coinfection in the Manaus, Amazon Region. Methods: This was a retrospective cohort study of TB/HIV coinfected patients over 18 years of age who were admitted to an ICU in the city of Manaus, Brazil, between January of 2011 and December of 2014. Sociodemographic, clinical, and laboratory var...
The importance of audiometric monitoring in patients with multidrug-resistant t...
Vasconcelos,Karla Anacleto de; Frota,Silvana Maria Monte Coelho; Ruffino-Netto,Antonio; Kritski,Afrânio LineuAbstract INTRODUCTION: A total of 771 cases of multidrug-resistant tuberculosis (MDR-TB) were reported in Brazil in 2014. Treatment of MDR-TB with aminoglycosides can produce serious side effects such as permanent and irreversible hearing loss, which occurs in 5-64% of cases, and severely compromise patient quality of life. The goal of this research was to evaluate auditory and vestibular side effects in patien...
Prevalence of latent Mycobacterium tuberculosis infection in prisoners
Navarro,Pedro Daibert de; Almeida,Isabela Neves de; Kritski,Afrânio Lineu; Ceccato,Maria das Graças; Maciel,Mônica Maria DelgadoABSTRACT Objective: To determine the prevalence of and the factors associated with latent Mycobacterium tuberculosis infection (LTBI) in prisoners in the state of Minas Gerais, Brazil. Methods: This was a cross-sectional cohort study conducted in two prisons in Minas Gerais. Tuberculin skin tests were performed in the individuals who agreed to participate in the study. Results: A total of 1,120 individuals were...