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Cloxacillin nanostructured formulation for the treatment of bovine keratoconjun...
Fonseca, Miriam das Dores Mendes; Maia, Júlia Marques da Silva; Varago, Fabiana Cristina; Gern, Juliana Carine; Carvalho, Wanessa AraújoInfectious bovine keratoconjunctivitis (IBK) is a widespread, contagious ocular disease that affects cattle, especially dairy breeds. The disease is caused by Gram-negative bacteria mainly Moraxella bovis, and its treatment consists of parenteral or topic antibiotic therapy. The topic treatment approach is used more commonly in lactating cows, to avoid milk disposal. However, treatment failures are common, beca...
Nanotubos de carbono aplicados às neurociências: perspectivas e desafios
Oliveira, Virginia; Pereira, Michele Munk; Brandão, Humberto de Mello; Brandão, Marcos Antônio Fernandes; Gattaz, Wagner FaridINTRODUÇÃO: Os nanotubos de carbono (NTCs) são os nanomateriais mais promissores para aplicação terapêutica em doenças neurodegenerativas. Aplicações potenciais incluem sistemas de liberação controlada de fármacos, interfaces elétricas e substratos para crescimento celular. OBJETIVO: Descrever o estado da arte e as perspectivas e desafios da aplicação dos NTCs nas neurociências. MÉTODO: Procedeu-se a uma busca ...
Relationship between virulence factor genes in coagulase-negative Staphylococcu...
Zafalon, Luiz Francisco; Cunha, Maria de Lourdes Ribeiro de Souza da; Brandão, Humberto de Mello; Mosqueira, Vanessa Carla FurtadoCoagulase-negative Staphylococcus spp. (CNS) are the main microorganisms involved in ovine mastitis. Treatment at the end of lactation can contribute towards cure and prevention of subclinical cases during the subsequent lactation. However, virulence factors and resistance mechanisms presented by CNS can decrease cure rates. The aims of the study were to identify the species of CNS in milk of mastitic ewes with...
Efficient delivery of DNA into bovine preimplantation embryos by multiwall carb...
Munk, Michele; Ladeira, Luiz Orlando; Carvalho, Bruno Campos de; Raposo, Nádia Rezende Barbosa; Serapião, Raquel V.; Quintão, Carolina Capobiango RomanoThe pellucid zone (PZ) is a protective embryonic cells barrier against chemical, physical or biological substances. This put, usual transfection methods are not efficient for mammal oocytes and embryos as they are exclusively for somatic cells. Carbon nanotubes have emerged as a new method for gene delivery, and they can be an alternative for embryos transfection, however its ability to cross the PZ and mediate...
Uso de antimicrobiano nanoparticulado para o tratamento da mastite subclínica d...
Santana, Raul Costa Mascarenhas; Zafalon, Luiz Francisco; Brandão, Humberto de Mello; Fim Júnior, Guilherme Aparecido; Pilon, Lucas EduardoA inflamação da glândula mamária é uma das principais causas de prejuízo na ovinocultura. Este estudo teve como objetivo investigar as taxas de cura do tratamento da mastite subclínica após infusão intramamária de princípio ativo antimicrobiano no momento da secagem, em formulações convencional e nanoparticulada. Os rebanhos estavam localizados em São Carlos, São Paulo, Brasil. Analisou-se um total de 584 glând...
Mastite bovina sob nanocontrole: a própolis nanoestruturada como nova perspecti...
Troncarelli, Marcela Zampoli [UNESP]; Brandão, Humberto de Mello; Gern, Juliana Carine; Guimarães, Alessandro de Sá; Langoni, Helio [UNESP]Made available in DSpace on 2016-07-07T12:35:55Z (GMT). No. of bitstreams: 0 Previous issue date: 2013. Added 1 bitstream(s) on 2016-07-07T12:44:54Z : No. of bitstreams: 1 ISSN0102-5716-2013-20-124-136.pdf: 541793 bytes, checksum: c91c664f2cc980ec9ddee5acd28c7b21 (MD5); A produção orgânica de leite preconiza o uso de medicamentos a base de fitoterapia e homeopatia para o controle da mastite nos rebanhos, em det...
Carbon nanotubes applied in neuroscience: prospects and challenges
Oliveira, Virginia; Pereira, Michele Munk; Brandão, Humberto de Mello; Brandão, Marcos Antônio Fernandes; Gattaz, Wagner FaridBACKGROUND: Carbon nanotubes (CNTs) are the most promising nanomaterials for therapeutic application in neurodegenerative diseases. Potential applications include systems for controlled drug delivery, electrical interfaces and substrates for cell growth. OBJECTIVE: To describe the state of art, prospects and challenges of applying CNTs in neuroscience. METHODS: There has been systematic search in Medline, Lilac...