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Enantioseparationof 3-chloromethcathinone by liquid chromatography at the milli...

The most prominent synthetic cathinone (SCAT)is 3-chloromethcathinone (3-CMC), accounting for 34% and 63.41% of the total seized new psychoactive substances (NPS) in Europe in 2021 and 2022, respectively [1, 2].Over the latest years, since the first identification on the European drug market in September 2014 in Sweden, 3-CMC has gained significant popularity among the younger drug users [3]. Moreover, 3-CMC is...

Enantiomeric biodistribution and toxicity of 3-chloromethcathinone (3-CMC) in W...

Background: There has been a surge in global attention to New Psychoactive Substances (NPS) [1]. Synthetic cathinones stand out as a widely consumed NPS class. Notably, 3-chloromethcathinone (3-CMC) accounted for over 34% of NPS seizures in 2021 [2], which underscores concerns regarding its consumption and health effects. Of note, 3-CMC is chiral and mostly sold as a racemate. As human metabolism and pharm...

Chemical differences between alternative and traditional tobacco products

Background: Electronic cigarettes (E-cigs) and heated tobacco products (HTPs) have gained popularity as alternatives to traditional tobacco products (TTPs), claiming to reduce harm. The carcinogenic properties of chemicals in the smoke of TTPs are widely recognized. However, there is still an incomplete understanding of the different chemicals in E-cigs and HTPs and their toxicity to human cells [1]. Objec...

Optimization of the derivatization procedure for the separation of the stereois...

Background: 1,3-Dimethylamylamine (1,3-DMAA), also known as methylhexanamine, is a central nervous system stimulant with structural similarities with amphetamines and therefore presenting overlapping biological and detrimental effects [1]. Despite being banned, the presence of 1,3-DMAA in doping controls and dietary supplements continues to be of significant concern. This molecule has two stereogenic centres an...

In vitro and in silico evaluation of psilocybin and psilocin’s interaction with...

Background: Psilocybin is a hallucinogen produced by “magic mushrooms”, being rapidly metabolized in the organism into psilocin [1, 2]. A scientific gap exists regarding the possible interactions between psilocybin/psilocin and CYP450 enzymes. Given their biological importance, and since the binding of drugs to CYP450 enzymes can interfere with the metabolism of other substrates leading to drug-drug interaction...

In vitro and in silico evaluation of 5-MeO-DMT, LSD, and mescaline’s interactio...

Background: 5-Methoxy-N,N-dimethyltryptamine (5-MeO-DMT), lysergic acid diethylamide (LSD), and mescaline are classic hallucinogens known for their recreational use, which increased in the last decades. Despite some available data on the metabolism of these drugs [1-3], a scientific gap exists regarding their possible interactions with CYP450 enzymes. Nevertheless, this information is of crucial relevance to pr...

Drug use among the student population of the University of Porto: Analysis of p...

Alcohol, tobacco, and illicit drugs use by university students is a complex issue that has garnered concern and interest from public health officials, educators, and scientific community [1]. This concern is driven by various factors, including the potential to affect academic performance and mental and physical health.This study was designed to determine the prevalence and patterns of psychotropic drug use amo...

Mitochondrial effects and Caspase-3 activation induced by synthetic cannabinoid...

Synthetic cannabinoids AMB-FUBINACA, ADB-FUBINACA, AB-CHMINACA and THJ-2201 imp...