2 documents found, page 1 of 1
Host immune genetic variations influence the risk of developing acute myeloid l...
Sánchez-Maldonado, J. M.; Campa, D.; Springer, J.; Badiola, J.; Niazi, Y.; Moñiz-Díez, A.; Hernández-Mohedo, F.; González-Sierra, P.; Ter Horst, R.The purpose of this study was to conduct a two-stage case control association study including 654 acute myeloid leukaemia (AML) patients and 3477 controls ascertained through the NuCLEAR consortium to evaluate the effect of 27 immune-related single nucleotide polymorphisms (SNPs) on AML risk. In a pooled analysis of cohort studies, we found that carriers of the IL13rs1295686A/A genotype had an increased risk of...
Polymorphisms in host immunity modulating genes and risk of invasive aspergillo...
Lupiañez, C. B.; Canet, L. M.; Carvalho, Agostinho Albérico Rodrigues de; Alcazar-Fuolie, L.; Springer, J.; Lacknerg, M.; Segura-Catena, J.; Comino, A.Recent studies suggest that immune-modulating single nucleotide polymorphisms (SNPs) influence the risk of developing cancer-related infections. Here, we evaluated whether 36 SNPs within 14 immune-related genes are associated with the risk of Invasive Aspergillosis (IA) and whether genotyping of these variants might improve disease risk prediction. We conducted a case-control association study of 781 immunocomp...