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Effects of oral supplementation of black-eyed-bean (Vigna unguiculata) in ICR m...

Ferreira, T; Silva-Reis, R; Mendes, BAL; Faustino-Rocha, AI; Carvalho, M; Castro I; Carnide, V; Coutinho, J; Gama, A; Rosa, E; Oliveira, PA

Grain legumes are a main source of nutrients in some countries. Black-eyed-bean (BEB) (Vigna unguiculata), a member of theFabaceae family, is a grain legume consumed worldwide due to its high content of bioactive molecules that promote human health. This study aimed to evaluate the effects of 70% BEB flour (BEBF) (w/w) supplementation in ICR healthy mice for 13 weeks. Body and organs weights, as well as food an...


Eficácia de intervenções dietéticas e nutricionais na diabetes gestacional – re...

Coelho, M; Coutinho, J; Pinto, E

Introdução: A diabetes gestacional é uma das complicações mais comuns da gravidez, associada a altos níveis de inflamação. É caracterizada por alterações do metabolismo glicémico e lipídico num ambiente de inflamação de baixo grau. A terapêutica nutricional tem demonstrado ser coadjuvante ou alternativa ao tratamento farmacológico. Objetivos: Rever sistematicamente e avaliar criticamente as diretrizes mais rece...


Decompressive Surgery in Cerebral Venous Sinus Thrombosis Due to Vaccine‐Induce...

Krzywicka, K; Aguiar de Sousa, D; Cordonnier, C; Bode, F; Field, T; Michalski, D; Pelz, J; Skjelland, M; Wiedmann, M; Zimmermann, J; Wittstock, M

Background and purpose: Cerebral venous sinus thrombosis due to vaccine-induced immune thrombotic thrombocytopenia (CVST-VITT) is an adverse drug reaction occurring after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination. CVST-VITT patients often present with large intracerebral haemorrhages and a high proportion undergoes decompressive surgery. Clinical characteristics, therapeutic manag...


Characteristics and Outcomes of Patients With Cerebral Venous Sinus Thrombosis ...

Sánchez van Kammen, M; Aguiar de Sousa, D; Poli, S; Cordonnier, C; Heldner, M; van de Munckhof, A; Krzywicka, K; van Haaps, T; Ciccone, A; Middeldorp, S

Importance: Thrombosis with thrombocytopenia syndrome (TTS) has been reported after vaccination with the SARS-CoV-2 vaccines ChAdOx1 nCov-19 (Oxford-AstraZeneca) and Ad26.COV2.S (Janssen/Johnson & Johnson). Objective: To describe the clinical characteristics and outcome of patients with cerebral venous sinus thrombosis (CVST) after SARS-CoV-2 vaccination with and without TTS. Design, setting, and participants: ...


Human serum pre-treatment: removal of abundant proteins aiming the concentratio...

Rosa, M; Silva, F; Coutinho, J; Freire, M

Due to the long asymptomatic phase and lack of effective early-stage diagnosis, lung cancer is one of the deadliest types of cancer worldwide. To expedite disease diagnosis, the quantification of target biomarkers in human serum is a propitious approach. However, the low concentrations of biomarkers in human serum and their tendency to be masked by abundant proteins [immunoglobulin G (IgG) and human serum album...


Parathyroid Cyst: Differential Diagnosis

Silva, R; Cavadas, D; Vicente, C; Coutinho, J

Parathyroid cysts are rare lesions of the cervical region and less frequently of the mediastinum. They occur mostly in women and are usually asymptomatic. They generally occur in the fourth and fifth decades of life and mainly are non-functioning. They commonly present as a neck mass that is found incidentally during surgery or in imaging test. Its importance lies in the difficulty in diagnosis, often confusing...



Recomendações para o diagnóstico, tratamento e monitorização da leucemia mielói...

Almeida, A; Castro, I; Coutinho, J; Guerra, L; Marques, H; Pereira, AM

Chronic Myeloid Leukemia (CML) is a clonal stem cell disease characterized by the expression of the fusion protein bcr-abl1, which has deregulated tirosine-kinase activity. Tyrosine kinase inhibitors (TKIs), and in particular imatinib, introduced fundamental changes in the treatment of CML, becoming, in most cases, the first-line treatment of choice in the chronic phase of this disease. Compared to other availa...


Carcinomas Espinocelulares Cutâneos em Doente com Epidermólise Bolhosa Distrófi...

Medeiros, S; Amaro, C; Oliveira, J; Catorze, G; Miguel, J; Coutinho, J; Vieira, R; Pacheco, A; Afonso, A; Cardoso, J

As epidermólises bolhosas (EB) hereditárias são um grupo heterogéneo de doenças bolhosas geneticamente determinadas. Caracterizam-se clinicamente por fragilidade mucocutânea que se traduz pela formação de 1,2 bolhas após traumatismos mínimos. Nas formas distróficas, principalmente na forma recessiva, as lesões cutâneas evoluem de forma crónica levando à formação de múltiplas cicatrizes atróficas e estão associa...


Neutropenia.

Leite, F; Coutinho, J

The authors reviewed the subject of neutropenia in what concern its definition, pathophysiology, clinical features, diagnosis and principles of treatment. A new pathophysiological classification of neutropenia and an evaluation of neutropenic patients are proposed. The extent of laboratory evaluation depends greatly on the duration and severity of the neutropenia. The hematopoietic growth factors controlling th...

Date: 1998   |   Origin: Acta Médica Portuguesa

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