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How DIS3L2 meets NMD-targets: I’m really into “U”!

da Costa, Paulo J.; Saramago, Margarida; Viegas, Sancra C.; Arraiano, Cecília M.; Romão, Luísa

The nonsense-mediated mRNA decay (NMD) pathway selectively degrades mRNAs carrying a premature translation-termination codon but also regulates the abundance of a large number of physiological RNAs that encode full-length proteins. Also, NMD regulates the levels of many physiological PTC-free mRNAs that encode full-length proteins. In human cells, NMD-targeted mRNAs are degraded by endonucleolytic cleavage and ...

Date: 2018   |   Origin: Repositório Científico do Instituto Nacional de Saúde
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