5 documents found, page 1 of 1
Decrease in APP and CP mRNA expression supports impairment of iron export in Al...
Guerreiro, C; Silva, B; Crespo, A; Marques, L; Costa, S; Timóteo, A; Marcelino, E; Maruta, C; Vilares, A; Matos, M; Couto, F; Faustino, P; Verdelho, AAlzheimer's disease (AD) is a neurodegenerative disorder of still unknown etiology and the leading cause of dementia worldwide. Besides its main neuropathological hallmarks, a dysfunctional homeostasis of transition metals has been reported to play a pivotal role in the pathogenesis of this disease. Dysregulation of iron (Fe) metabolism in AD has been suggested, particularly at the level of cellular iron efflux...
Extended polymerization in ABC-stacked C-70 fullerite
Marques, L; Skorokhod, Y; Soares, RThis letter reports on the extended polymerization occurring in ABC stacked C70 fullerite, which up to now was thought to occur only in the AB stacked phase. Frustration effects on ABC close packing of C70 molecules were believed to prevent extended polymerization based on 2 + 2 cycloaddition bonds, but here we show that an extended polymeric phase is obtained at 10 GPa and 270 C. Its structure, obtained by Rie...
Genetic and biochemical markers in patients with Alzheimer's disease support a ...
Crespo, A; Silva, B; Marques, L; Marcelino, E; Maruta, C; Costa, S; Timóteo, A; Vilares, A; Couto, F; Faustino, P; Correia, AP; Verdelho, A; Porto, GAlzheimer's disease (AD) is the most common form of dementia in the elderly individuals, resulting from a complex interaction between environmental and genetic factors. Impaired brain iron homeostasis has been recognized as an important mechanism underlying the pathogenesis of this disease. Nevertheless, the knowledge gathered so far at the systemic level is clearly insufficient. Herein, we used an integrative ...
Severe Isolated Thrombocytopenia After Clopidogrel and Pentoxifylline Therapy: ...
Vedes, E; Marques, L; Rico, MINTRODUCTION: Clopidogrel is frequently associated with thrombotic thrombocytopenic purpura, however this drug is rarely related to severe isolated thrombocytopenia. Pentoxifylline has previously been associated with thrombocytopenia only once. To the best of our knowledge, this is the first report of severe isolated thrombocytopenia after therapy with both clopidogrel and pentoxyfilline. CASE PRESENTATION: We ...
Children and lead exposure. Preliminary study.
Mayan, O; Marques, L; Duarte, R; Henriques, A; Bastos, A; Alves, D; Calheiros, JLead poisoning is one of the most common and preventable childhood illness. The authors believe that the present study is the first evaluation of this problem in Portugal. Objectives: a) to characterize blood lead levels in children aged 1 to 6 years living in the Oporto area; b) to identify risk groups and develop screening strategies. Material and methods: The authors studied an opportunistic sample of childr...