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Mapping age- and sex-specific HIV prevalence in adults in sub-Saharan Africa, 2...

Haeuser, E; Serfes, AL; Cork, MA; Yang, M; Abbastabar, H; Abhilash, ES; Adabi, M; Adebayo, OM; Adekanmbi, V; Adeyinka, DA; Afzal, S; Ahinkorah, BO

Background: Human immunodeficiency virus and acquired immune deficiency syndrome (HIV/AIDS) is still among the leading causes of disease burden and mortality in sub-Saharan Africa (SSA), and the world is not on track to meet targets set for ending the epidemic by the Joint United Nations Programme on HIV/AIDS (UNAIDS) and the United Nations Sustainable Development Goals (SDGs). Precise HIV burden information is...


Subnational mapping of HIV incidence and mortality among individuals aged 15–49...

Sartorius, B; VanderHeide, JD; Yang, M; Goosmann, EA; Hon, J; Haeuser, E; Cork, MA; Perkins, S; Jahagirdar, D; Schaeffer, LE; Serfes, AL; LeGrand, KE

Background. High-resolution estimates of HIV burden across space and time provide an important tool for tracking and monitoring the progress of prevention and control efforts and assist with improving the precision and efficiency of targeting efforts. We aimed to assess HIV incidence and HIV mortality for all second-level administrative units across sub-Saharan Africa. Methods. In this modelling study, we devel...


Paving Luteolin Therapeutic Potentialities and Agro-Food-Pharma Applications: E...

Taheri, Y; Sharifi-Rad, J; Antika, G; Yilmaz, YB; Tumer, TB; Abuhamdah, S; Chandra, S; Saklani, S; Kiliç, CS; Sestito, S; Dastan, SD; Kumar, M

Luteolin is a naturally occurring secondary metabolite belonging to the class of flavones. As many other natural flavonoids, it is often found in combination with glycosides in many fruits, vegetables, and plants, contributing to their biological and pharmacological value. Many preclinical studies report that luteolin present excellent antioxidant, anticancer, antimicrobial, neuroprotective, cardioprotective, a...


Mapping subnational HIV mortality in six Latin American countries with incomple...

Cork, MA; Henry, NJ; Watson, S; Croneberger, AJ; Baumann, M; Letourneau, ID; Yang, M; Serfes, AL; Abbas, J; Abbasi, N; Abbastabar, H; Abreu, LG

Background: Human immunodeficiency virus (HIV) remains a public health priority in Latin America. While the burden of HIV is historically concentrated in urban areas and high-risk groups, subnational estimates that cover multiple countries and years are missing. This paucity is partially due to incomplete vital registration (VR) systems and statistical challenges related to estimating mortality rates in areas w...


Anemia prevalence in women of reproductive age in low- and middle-income countr...

Kinyoki, D; Osgood-Zimmerman, AE; Bhattacharjee, NV; Schaeffer, LE; Lazzar-Atwood, A; Lu, D; Ewald, SB; Donkers, KM; Letourneau, ID; Collison, M

Anemia is a globally widespread condition in women and is associated with reduced economic productivity and increased mortality worldwide. Here we map annual 2000–2018 geospatial estimates of anemia prevalence in women of reproductive age (15–49 years) across 82 low- and middle-income countries (LMICs), stratify anemia by severity and aggregate results to policy-relevant administrative and national levels. Addi...


Glycyrrhiza Genus: Enlightening Phytochemical Components for Pharmacological an...

Sharifi-Rad, J; Quispe, C; Herrera-Bravo, J; Belén, LH; Kaur, R; Kregiel, D; Uprety, Y; Beyatli, A; Yeskaliyeva, B; Kirkin, C; Özçelik, B; Sen, S

The Glycyrrhiza genus, generally well-known as licorice, is broadly used for food and medicinal purposes around the globe. The genus encompasses a rich pool of bioactive molecules including triterpene saponins (e.g., glycyrrhizin) and flavonoids (e.g., liquiritigenin, liquiritin). This genus is being increasingly exploited for its biological effects such as antioxidant, antibacterial, antifungal, anti-inflammat...


Cyperus spp.: A Review on Phytochemical Composition, Biological Activity, and H...

Taheri, Y; Herrera-Bravo, J; Huala, L; Salazar, LA; Sharifi-Rad, J; Akram, M; Shahzad, K; Melgar-Lalanne, G; Baghalpour, N; Tamimi, K

Cyperaceae are a plant family of grass-like monocots, comprising 5600 species with a cosmopolitan distribution in temperate and tropical regions. Phytochemically, Cyperus is one of the most promising health supplementing genera of the Cyperaceae family, housing ˜950 species, with Cyperus rotundus L. being the most reported species in pharmacological studies. The traditional uses of Cyperus spp. have been report...


Phenolic Bioactives as Antiplatelet Aggregation Factors: The Pivotal Ingredient...

Sharifi-Rad, J; Quispe, C; Zam, W; Kumar, M; Cardoso, SM; Pereira, OR; Ademiluyi, AO; Adeleke, O; Moreira, AC; Živkovic, J; Noriega, F; Ayatollahi, SA

Cardiovascular diseases (CVD) are one of the main causes of mortality in the world. The development of these diseases has a specific factor-alteration in blood platelet activation. It has been shown that phenolic compounds have antiplatelet aggregation abilities and a positive impact in the management of CVD, exerting prominent antioxidant, anti-inflammatory, antitumor, cardioprotective, antihyperglycemic, and ...


Mapping inequalities in exclusive breastfeeding in low- and middle-income count...

Bhattacharjee, NV; Schaeffer, LE; Hay, SI; Lu, D; Schipp, MF; Lazzar-Atwood, A; Donkers, KM; Abady, GG; Abd-Allah, F; Abdelalim, A; Abebo, ZH

Exclusive breastfeeding (EBF)-giving infants only breast-milk for the first 6 months of life-is a component of optimal breastfeeding practices effective in preventing child morbidity and mortality. EBF practices are known to vary by population and comparable subnational estimates of prevalence and progress across low- and middle-income countries (LMICs) are required for planning policy and interventions. Here w...


Chemical Composition, Biological Activity, and Health-Promoting Effects of With...

Sharifi-Rad, J; Quispe, C; Ayatollahi, SA; Kobarfard, F; Staniak, M; Stepien, A; Czopek, K; Sen, S; Acharya, K; Matthews, KR; Sener, B; Devkota, HP

The Withania genus comes from the Solanaceae family and includes around 23 species, spread over some areas of the Mediterranean, Asia, and East Africa. Widely used in traditional medicine for thousands of years, these plants are rich in secondary metabolites, with special emphasis on steroidal lactones, named withanolides which are used as ingredients in numerous formulations for a plethora of diseases, such as...


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