6 documents found, page 1 of 1
Global age-sex-specific mortality, life expectancy, and population estimates in...
Schumacher, AE; Kyu, HH; Aali, A; Abbafati, C; Abbas, J; Abbasgholizadeh, R; Abbasi, MA; Abbasian, M; Abd ElHafeez, S; Abdelmasseh, M; Abd Elsalam, SBackground: Estimates of demographic metrics are crucial to assess levels and trends of population health outcomes. The profound impact of the COVID-19 pandemic on populations worldwide has underscored the need for timely estimates to understand this unprecedented event within the context of long-term population health trends. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 provides n...
Presence of Multilobular Necrosis on Liver Biopsy Identifies Corticosteroid Res...
Lin, S; Araújo, C; Hall, A; Kumar, R; Phillips, A; Hassan, M; Engelmann, C; Quaglia, A; Jalan, RBackground and aims: Treatment of patients with severe indeterminate hepatitis (IAH) is an unmet need. Corticosteroids are often used in the management of these patients but criteria for the selection of patients for this intervention are arbitrary. The aims of this study were to analyse the clinical and pathological features of patients with IAH to define predictors of corticosteroid responsiveness. Methods: T...
Prognostic Role of Liver Biopsy in Patients With Severe Indeterminate Acute Hep...
Lin, S; Araujo, C; Hall, A; Kumar, R; Phillips, A; Hassan, M; Engelmann, C; Quaglia, A; Jalan, RBackground and aims: Severe indeterminate acute hepatitis (sIAH) is a poorly understood rare disease with no specific therapy. This study aims to define the clinicopathological characteristics of sIAH and the role of liver biopsy in determining prognosis. Methods: Patients with sIAH admitted to a single center between 2010 and 2019 were included. Histopathological patterns of liver biopsies were reviewed by 2 h...
Human lower limb activity recognition techniques, databases, challenges and its...
Vijayvargiya, A; Singh, B; Kumar, R; João Manuel R. S. TavaresHuman lower limb activity recognition (HLLAR) has grown in popularity over the last decade mainly because to its applications in the identification and control of neuromuscular disorders, security, robotics, and prosthetics. Surface electromyography (sEMG) sensors provide various advantages over other wearable or visual sensors for HLLAR applications, including quick response, pervasiveness, no medical monitori...
Stillbirths: Rates, risk factors, and acceleration towards 2030
Lawn, JE; Blencowe, H; Waiswa, P; Amouzou, A; Mathers, C; Hogan, D; Flenady, V; Frøen, JF; Qureshi, ZU; Calderwood, C; Shiekh, S; Jassir, FB; You, DAn estimated 2·6 million third trimester stillbirths occurred in 2015 (uncertainty range 2·4-3·0 million). The number of stillbirths has reduced more slowly than has maternal mortality or mortality in children younger than 5 years, which were explicitly targeted in the Millennium Development Goals. The Every Newborn Action Plan has the target of 12 or fewer stillbirths per 1000 births in every country by 2030. ...
Mutations in CTC1, Encoding Conserved Telomere Maintenance Component 1, Cause C...
Anderson, B; Kasher, P; Mayer, J; Szynkiewicz, M; Jenkinson, E; Bhaskar, S; Urquhart, J; Daly, S; Dickerson, J; O'Sullivan, J; Leibundgut, E; Muter, JCoats plus is a highly pleiotropic disorder particularly affecting the eye, brain, bone and gastrointestinal tract. Here, we show that Coats plus results from mutations in CTC1, encoding conserved telomere maintenance component 1, a member of the mammalian homolog of the yeast heterotrimeric CST telomeric capping complex. Consistent with the observation of shortened telomeres in an Arabidopsis CTC1 mutant and t...