3 documents found, page 1 of 1
Forecast cancer: the importance of biomimetic 3D in vitro models in cancer drug...
Caballero, David; Kundu, B.; Abreu, Catarina M.; Amorim, S.; Fernandes, D. C.; Pires, R. A.; Oliveira, Joaquim M.; Correlo, V. M.; Reis, R. L.Nowadays, the pharmaceutical industry faces a significant challenge related to the high attrition rates of drugs, which is particularly astonishing in oncology [1]. Indeed, several studies have reported that about 95% of anti-cancer drugs tested in phase I fail to reach the market. The reasons for this decline may be very complex, but most likely, they are related to how potential drug candidates are tested, wh...
Chinese oak tasar silkworm antheraea pernyi silk Proteins: Current strategies a...
Silva, S. S.; Kundu, B.; Lu, S.; Reis, R. L.; Kundu, Subhas CChinese nonmulberry temperate oak tasar/tussah, Antheraea pernyi (Ap) silk is a natural biopolymer that has attracted considerable attention as a biomaterial. The proteinaceous components of Ap silk proteins, namely fbroin and sericin may represent an alternative over mulberry Bombyx mori silk proteins. In fact, the silk fbroin (SF) of Ap is rich in Arginyl-Glycyl-Aspartic acid (RGD) peptides, which facilitate ...
Template mediated protein self-assembly as a valuable tool in regenerative therapy
Kundu, B.; Eltohamy, M.; Yadavalli, V. K.; Reis, R. L.; Kim, H. W.The assembly of natural proteinaceous biopolymers into macro-scale architectures is of great importance in synthetic biology, soft-material science and regenerative therapy. The self-assembly of protein tends to be limited due to anisotropic interactions among protein molecules, poor solubility and stability. Here, we introduce a unique platform to self-immobilize diverse proteins (fibrous and globular, positiv...